2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Cibotercept

Cibotercept  (Synonyms: KER-012)

目录号: HY-P990733 纯度: 99.85%
COA 技术支持

Cibotercept (KER-012) 是一种新型修饰的激活素受体 IIB (ActRIIB) 配体陷阱，旨在靶向特定的 TGF-β 配体 (包括激活素 A 和 B、GDF8 和 GDF11)，以重新平衡肺动脉高压 (PAH) 中观察到的缺陷性激活素受体 II 信号。

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CAS No. : 2769700-97-0

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规格 价格 是否有货 数量
1 mg ￥2500
In-stock
5 mg ￥7500
In-stock
10 mg ￥12000
In-stock
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Cibotercept 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH[1][2].

IC50 & Target

MSTN/INHBA/GDF11
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • FPIA_[PROTEIN]2-FC
Biological Activity
  • Immobilized Activin A Protein, Human/Mouse/Rat (HEK293, HY-P70311) can bind Cibotercept. The EC50 for this effect is 32.97 ng/mL.
  • Immobilized GDF-11/BMP-11 Protein, Human (HEK293, solution, HY-P70222Y) can bind Cibotercept. The EC50 for this effect is 66.34 ng/mL.
纯度 & 产品资料
参考文献

Cibotercept 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Cibotercept2769700-97-0KER-012KER012KER 012TGF-beta/SmadTransforming growth factor betaInhibitorinhibitorinhibit

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