2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Luspatercept

Luspatercept  (Synonyms: ACE-536; luspatercept–aamt)

目录号: HY-P99720 纯度: 98.92%
COA

摩尔计算器

Luspatercept (ACE-536) 是一种重组修饰的 ActRIIB 融合蛋白，可与转化生长因子 β 超家族配体结合。Luspatercept 增加红细胞数量，促进红细胞前体成熟。Luspatercept 与 GDF11 结合，抑制 Smad2/3 信号通路。Luspatercept 可用于贫血的研究。

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Luspatercept Chemical Structure

Luspatercept Chemical Structure

CAS No. : 1373715-00-4

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Luspatercept 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia[1].

体外研究
(In Vitro)

Luspatercept (0.1-1000 ng/mL) 抑制 A204 细胞中 GDF11 和 GDF8 诱导的 Smad2 和 Smad 3 信号通路[1]。
Luspatcept 与 GDF11，GDF8，activin B，BMP10 和 BMP6 结合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Luspatercept 相关抗体:
体内研究
(In Vivo)

Luspatercept (0.1-60mg /kg，皮下注射；10mg /kg，静脉注射；每周 2 次，共 8 周) 增加小鼠、大鼠和猴子的红细胞 (RBC) 数量、血红蛋白水平和红细胞堆积[1]。
Luspatercept (10mg /kg，皮下注射，1 次) 降低 C57BL/6 小鼠骨髓和脾脏中的红细胞形成单位 (BFU-Es) 和红血球形成单位 (CFU-Es)[1]。
Luspatercept (10mg /kg，腹腔注射，1 次) 抑制小鼠脾脏 Smad2/3 磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[1]
Dosage: 0.1, 0.3, 1, 3 and 10 mg/kg
Administration: Subcutaneous injection and intravenous injection; 0.1-10 mg/kg (C57BL/6 mice, s.c.), 6-60 mg/kg (Sprague Dawley rats, s.c.), 0.4-30 mg/kg (cynomolgus monkeys, s.c.), 10 mg/kg, (cynomolgus monkeys, i.v.); twice weekly for 8 weeks
Result: Dose-dependently increased the level of RBC, hemoglobin and hematocrit in mice, rats and monkeys.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.92%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Luspatercept 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

Luspatercept1373715-00-4ACE-536 luspatercept–aamtACE536ACE 536TGF-beta/SmadTransforming growth factor betafusion proteinerythrocyteerythroid precursoranemiaBFU-ECFU-EmiceInhibitorinhibitorinhibit

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