2. Gene
  3. Eif2ak1 - eukaryotic translation initiation factor 2 alpha kinase 1 Gene

Eif2ak1 - eukaryotic translation initiation factor 2 alpha kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: HCR; Hri

基因 ID: 15467 | 基因类型: protein coding

关于 Eif2ak1

功能概要

Enables heme binding activity; protein homodimerization activity; and protein kinase activity. Involved in negative regulation of cell population proliferation and negative regulation of Hemoglobin biosynthetic process. Acts upstream of or within several processes, including macrophage differentiation; protoporphyrinogen IX metabolic process; and regulation of cellular macromolecule biosynthetic process. Located in cytoplasm. Is expressed in alimentary system; central nervous system; liver; nervous system; and spinal cord. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak1 基因产物(1)

mRNA Protein Name
NM_013557.2 NP_038585.2 eukaryotic translation initiation factor 2-alpha kinase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heme binding IDA
IDA: 通过直接分析推断
10671563 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
21223507 MGI
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
11560503 MGI
enables protein kinase activity IMP
IMP: 通过突变表型推断
11726526 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within acute inflammatory response IMP
IMP: 通过突变表型推断
17932563 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
17932563 MGI
acts upstream of or within macrophage differentiation IMP
IMP: 通过突变表型推断
17932563 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: 通过突变表型推断
17932563 MGI
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11050009 MGI
involved in negative regulation of hemoglobin biosynthetic process IDA
IDA: 通过直接分析推断
11050009 MGI
acts upstream of or within phagocytosis IMP
IMP: 通过突变表型推断
17932563 MGI
involved in protein autophosphorylation IEP
IEP: 通过表达模式推断
11560503 MGI
acts upstream of or within protoporphyrinogen IX metabolic process IGI
IGI: 通过遗传相互作用推断
15931390 MGI
acts upstream of or within regulation of eIF2 alpha phosphorylation by heme IGI
IGI: 通过遗传相互作用推断
15931390 MGI
acts upstream of or within regulation of hemoglobin biosynthetic process IGI
IGI: 通过遗传相互作用推断
15931390 MGI
acts upstream of or within regulation of translation IMP
IMP: 通过突变表型推断
11726526 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11050009 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

eukaryotic translation initiation factor 2-alpha kinase 1

heme-controlled repressor

heme-regulated eukaryotic initiation factor eIF-2-alpha kinase

heme-regulated inhibitor

hemin-sensitive initiation factor 2-alpha kinase

Eif2ak1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Eif2ak1 Q9Z2R9 Eif2s1 Mus musculus Q6ZWX6
Protein Kinase Assay
21223507
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04242 EIF2AK1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS04243 EIF2AK2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174720 Human EIF2AK2 mRNA / 否
HY-RS22002 Eif2ak1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28519 Eif2ak1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Eif2ak1 NCBI NCBI:27102
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