2. Gene
  3. Irf4 - interferon regulatory factor 4 Gene

Irf4 - interferon regulatory factor 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Spip; IRF-4; LSIRF; NF-EM5

基因 ID: 16364 | 基因类型: protein coding

关于 Irf4

功能概要

Enables DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Involved in several processes, including T-helper 17 cell lineage commitment; defense response to protozoan; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including histone acetylation; myeloid dendritic cell differentiation; and negative regulation of Toll-like Receptor signaling pathway. Part of nucleosome. Is expressed in eye; hemolymphoid system; liver; and testis. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; anaplastic large cell lymphoma; chronic lymphocytic leukemia; multiple myeloma; and peripheral T-cell lymphoma. Orthologous to human IRF4 (interferon regulatory factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Irf4 基因产物(2)

mRNA Protein Name
NM_001347508.1 NP_001334437.1 interferon regulatory factor 4 isoform b
NM_013674.2 NP_038702.1 interferon regulatory factor 4 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
22983707 MGI
enables cis-regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
30413670 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16236719 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
22983707 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
30413670 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T-helper 17 cell lineage commitment IMP
IMP: 通过突变表型推断
22983707 MGI
acts upstream of or within chromatin remodeling IMP
IMP: 通过突变表型推断
16428437 MGI
involved in defense response to protozoan IMP
IMP: 通过突变表型推断
22992524 MGI
acts upstream of or within myeloid dendritic cell differentiation IMP
IMP: 通过突变表型推断
15184678 MGI
involved in myeloid dendritic cell differentiation IMP
IMP: 通过突变表型推断
22992524 MGI
acts upstream of or within negative regulation of toll-like receptor signaling pathway IMP
IMP: 通过突变表型推断
16236719 MGI
acts upstream of or within positive regulation of DNA binding IMP
IMP: 通过突变表型推断
16428437 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
30413670 MGI
involved in positive regulation of DNA-templated transcription IGI
IGI: 通过遗传相互作用推断
28338898 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
24995979 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16428437 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of nucleosome IDA
IDA: 通过直接分析推断
16428437 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interferon regulatory factor 4

PU.1 interaction partner

Sfpi1/PU.1 interaction partner

lymphocyte-specific interferon regulatory factor

transcriptional activator PIP

Irf4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Irf4 Q64287 Ppargc1a Mus musculus O70343
Anti Bait CoIP
24995979
种属内
Irf4 Q64287 Batf Mus musculus O35284
Anti Bait CoIP
23021777
种属内
Irf4 Q64287 Batf Mus musculus O35284
CH-IP
23021777
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-130800 Eragidomide 99.93% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-172085 SH514 99.94% 否
HY-172614 RK-0080552 Inhibitor / 否
HY-RS06908 IRF4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16800 Irf4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23241 Irf4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Irf4 NCBI NCBI:3662
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