2. Gene
  3. Trpm4 - transient receptor potential cation channel, subfamily M, member 4 Gene

Trpm4 - transient receptor potential cation channel, subfamily M, member 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Mls2s; LTrpC-4

基因 ID: 171143 | 基因类型: protein coding

关于 Trpm4

功能概要

Enables calcium activated cation channel activity. Involved in several processes, including ion homeostasis; negative regulation of osteoblast differentiation; and regulation of blood circulation. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and neuronal cell body. Biomarker of cardiac arrest. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 6 and progressive familial heart block type IB. Orthologous to human TRPM4 (transient receptor potential cation channel subfamily M member 4). [provided by Alliance of Genome Resources, Apr 2022]

Trpm4 基因产物(1)

mRNA Protein Name
NM_001136229.1 NP_001129701.1 transient receptor potential cation channel subfamily M member 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium-activated cation channel activity IDA
IDA: 通过直接分析推断
19945433 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
24114458 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in long-term memory IMP
IMP: 通过突变表型推断
29971514 RGD
involved in negative regulation of bone mineralization IMP
IMP: 通过突变表型推断
23081848 RGD
involved in negative regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
23081848 RGD
involved in positive regulation of adipose tissue development IMP
IMP: 通过突变表型推断
23081848 RGD
involved in positive regulation of atrial cardiac muscle cell action potential IMP
IMP: 通过突变表型推断
23954346 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
23081848 RGD
involved in positive regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
23081848 RGD
involved in positive regulation of heart rate IMP
IMP: 通过突变表型推断
23954346 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
16806463 RGD
involved in positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization IMP
IMP: 通过突变表型推断
20826763 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
15472118 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
19945433 RGD
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
19945433 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
21848647 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
19945433 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transient receptor potential cation channel subfamily M member 4

LTrpC4

calcium-activated non-selective cation channel 1

long transient receptor potential channel 4

melastatin like 2 protein

melastatin-like 2

相关产品

Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110220 CIM0216 Agonist 99.94% 否
HY-14307 Necrocide 1 98.84% 否
HY-128172 TRPM4-IN-2 Inhibitor 99.17% 否
HY-108457 9-Phenanthrol Inhibitor 99.61% 否
HY-122605 TRPM4-IN-1 Inhibitor 99.98% 否
HY-139192 Brophenexin 99.59% 否
HY-153468 ErSO-TFPy Activator 99.33% 否
HY-139192A Brophenexin free base 99.24% 否
HY-170302 CMP233 Inhibitor / 否
HY-170790 HZS60 Inhibitor / 否
HY-RS15114 TRPM4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W611371 FP802 Inhibitor / 否
HY-RS17210 Trpm4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23662 Trpm4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Trpm4 NCBI NCBI:54795
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