1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. CIM0216

CIM0216 

目录号: HY-110220 纯度: ≥98.0%
产品使用指南

CIM0216 是一种强效选择性 TRPM3 激动剂,能够打开 TRPM3 中两个不同的阳离子渗透孔。CIM0216 对 TRPM3 的选择性高于TRPM1、TRPM2 和 TRPM4-8。CIM0216 是研究 TRPM3 生理作用的有力工具,并可用于神经源性炎症的研究。

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CIM0216 Chemical Structure

CIM0216 Chemical Structure

CAS No. : 1031496-06-6

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Description

CIM0216, a potent and selective agonist of TRPM3, has the ability to open two distinct cation-permeable pores in TRPM3. CIM0216 exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. CIM0216 acts as a powerful tool for use in investigating the physiological roles of TRPM3, and can be used for neurogenic inflammation research[1].

IC50 & Target[1]

TRPM3

 

In Vitro

CIM0216 elicits a dose-dependent Ca2+ response [pEC50=0.77±0.1 µM] in HEK-TRPM3 cells, which is not observed in nontransfected HEK293 cells. CIM0216 induces a robust increase in intracellular Ca2+ concentration (1,145±26 nM) in single-cell FURA2-ratiometric Ca2+ imaging in HEK-TRPM3 cells. These responses are not observed in nontransfected HEK cells or in the absence of extracellular Ca2+[1].
CIM0216 (10 µM) has no stimulating/blocking effect on TRPM1, TRPM4, TRPM6, or TRPM7 currents; however, a small blocking effect of CIM0216 is observed after activation of TRPM2 (16.6% block) and TRPM5 (33.5% block). CIM0216 also has no detectable effect on human TRPV1 and TRPM8 channel activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

347.41

Formula

C₂₁H₂₁N₃O₂

CAS No.

1031496-06-6

SMILES

CC1=CC(NC(C(C2=CC=CC=C2)N3C4=CC=CC=C4CCC3)=O)=NO1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥98.0%

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Keywords:

CIM0216CIM 0216CIM-0216TRP ChannelTransient receptor potential channelsTRPM3neurogenicinflammationsensory nerveInhibitorinhibitorinhibit

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产品名称:
CIM0216
目录号:
HY-110220
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