2. Gene
  3. Smad1 - SMAD family member 1 Gene

Smad1 - SMAD family member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mad1; Mlp1; Madh1; Madr1; dwf-A; mMad1; MusMLP

基因 ID: 17125 | 基因类型: protein coding

关于 Smad1

功能概要

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and nucleic acid binding activity. Involved in several processes, including osteoblast differentiation; positive regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including animal organ development; osteoblast fate commitment; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human SMAD1 (Smad Family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Smad1 基因产物(1)

mRNA Protein Name
NM_008539.4 NP_032565.2 mothers against decapentaplegic homolog 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
14633973 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
21976273 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
18692037 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21724602 MGI
enables primary miRNA binding IDA
IDA: 通过直接分析推断
21145505 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12370310 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23169531 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within BMP signaling pathway IDA
IDA: 通过直接分析推断
25100727 MGI
involved in BMP signaling pathway IDA
IDA: 通过直接分析推断
21976273 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
16604073 MGI
involved in BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
19252488 MGI
acts upstream of or within BMP signaling pathway IMP
IMP: 通过突变表型推断
15198985 MGI
acts upstream of or within MAPK cascade IMP
IMP: 通过突变表型推断
15198985 MGI
involved in SMAD protein signal transduction IGI
IGI: 通过遗传相互作用推断
19252488 MGI
acts upstream of or within bone development IGI
IGI: 通过遗传相互作用推断
19224984 MGI
acts upstream of or within cardiac muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
17350578 MGI
acts upstream of or within cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
17350578 MGI
acts upstream of or within cartilage development IGI
IGI: 通过遗传相互作用推断
19224984 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
15899870 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
19103752 MGI
acts upstream of or within gamete generation IMP
IMP: 通过突变表型推断
15198985 MGI
acts upstream of or within hindbrain development IMP
IMP: 通过突变表型推断
15899870 MGI
acts upstream of or within homeostatic process IMP
IMP: 通过突变表型推断
15198985 MGI
involved in inflammatory response IEP
IEP: 通过表达模式推断
12151307 MGI
acts upstream of or within mesodermal cell fate commitment IGI
IGI: 通过遗传相互作用推断
16801560 MGI
acts upstream of or within midbrain development IMP
IMP: 通过突变表型推断
15899870 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15899870 MGI
involved in negative regulation of muscle cell differentiation IDA
IDA: 通过直接分析推断
21976273 MGI
involved in osteoblast differentiation IDA
IDA: 通过直接分析推断
7798324 MGI
acts upstream of or within osteoblast fate commitment IGI
IGI: 通过遗传相互作用推断
15150273 MGI
acts upstream of or within positive regulation of cartilage development IDA
IDA: 通过直接分析推断
19251704 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: 通过突变表型推断
18622394 MGI
involved in positive regulation of miRNA transcription IMP
IMP: 通过突变表型推断
21145505 MGI
acts upstream of or within positive regulation of osteoblast differentiation IGI
IGI: 通过遗传相互作用推断
15150273 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15557274 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
24211589 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
20843790 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
34995814 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
18776146 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12270938 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18997172 MGI
involved in ureteric bud development IEP
IEP: 通过表达模式推断
14656760 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11160896 MGI
part of homomeric SMAD protein complex IPI
IPI: 通过物理相互作用推断
20147459 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
21976273 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12151307 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
14633973 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mothers against decapentaplegic homolog 1

MAD homolog 1

dwarfin-A

mad-related protein 1

mothers against DPP homolog 1

mothers-against-DPP-related 1

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-145608 Zilurgisertib Inhibitor 98.25% Phase 2
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99359 Elezanumab Inhibitor 99.69% Phase 2
HY-P99353 Ascrinvacumab Inhibitor 97.45% Phase 2
Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-124697 BMP signaling agonist sb4 Agonist 99.98% 否
HY-108527 CD1530 98.01% 否
HY-12274 ML347 Inhibitor 99.94% 否
HY-147372 SJ000063181 Activator 98.92% 否
HY-164145 CDD-1653 99.38% 否
HY-123900 AZ12799734 Inhibitor 98.67% 否
HY-148234 M4K2234 Inhibitor 98.31% 否
HY-N0946 (-)-Pinoresinol 4-O-glucoside Inhibitor ≥98.0% 否
HY-173149 CDD-2789 Inhibitor / 否
HY-174416 Smurf1-IN-5 Inhibitor / 否
HY-RS05279 GARS1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13392 SMAD1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18190 Smad1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24664 Smad1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smad1 NCBI NCBI:4086
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