2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK)
  4. Ascrinvacumab

Ascrinvacumab  (Synonyms: Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab); PF-03446962)

目录号: HY-P99353 纯度: 97.45%
COA

摩尔计算器

Ascrinvacumab (PF-03446962) 是一种人 IgG2 单克隆抗体，靶向 ALK-1。Ascrinvacumab 显示出与人 ALK1 的结合效能，Kd 值为 7 nM。Ascrinvacumab 可用于肝细胞癌 (HCC) 的研究。

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Ascrinvacumab Chemical Structure

Ascrinvacumab Chemical Structure

CAS No. : 1463459-96-2

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Ascrinvacumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC)[1].

体外研究
(In Vitro)

Ascrinvacumab 与细胞人 ALK1 结合，Kd 值为 7 nm[1]。
Ascrinvacumab (30 分钟) 阻断 BMP9 和 FCS 诱导的应答，缓解 BMP9 诱导的 Smad1 磷酸化强度和持续时间[1]。
Ascrinvacumab (0.01-10 μg/mL; 2 h) 抑制 BMP9 结合到 ALK1[1]。
Ascrinvacumab (40 μg/mL; 2 h) 有效抑制人脐静脉内皮细胞 (HUVECs) 的内皮萌发[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ascrinvacumab 相关抗体:
体内研究
(In Vivo)

Ascrinvacumab 联合贝伐单抗 (bevacizumab; anti-VEGF) 可降低人血管密度，提高抗肿瘤疗效在小鼠嵌合体肿瘤模型中[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 97.45%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Ascrinvacumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ascrinvacumab1463459-96-2Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab) PF-03446962PF03446962PF 03446962PF-03446962Anaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246HCCBMP9FCSSmad1phosphorylationHUVECbevacizumabInhibitorinhibitorinhibit

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