2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Elezanumab

Elezanumab  (Synonyms: 依来努单抗; ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab))

目录号: HY-P99359 纯度: 99.69%
COA

摩尔计算器

Elezanumab (ABT-555; AE12-1Y-QL) 是一种人单克隆抗体，可选择性靶向排斥性引导分子 A (RGMa)。Elezanumab 通过 SMAD1/5/8 通路有效抑制 RGMa 介导的 BMP 信号传导，IC50 约为 97 pM。Elezanumab 促进神经元损伤和脱髓鞘模型中的神经再生和神经保护作用，可结合 N 末端 RGMa、阻断 BMP 信号传导并缺乏 RGMc 交叉反应性。Elezanumab 具有神经再生和神经保护活性，对铁代谢没有影响。

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Elezanumab Chemical Structure

Elezanumab Chemical Structure

CAS No. : 1791416-49-3

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规格 价格 是否有货 数量
1 mg ￥2800
In-stock
5 mg ￥7200
In-stock
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Elezanumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism[1][2].

体内研究
(In Vivo)

Elezanumab (ABT-555; AE12-1Y-QL; 1-10 mg/kg; 静脉给药; 每周一次; 共 5 剂) 在视神经挤压和视神经炎雌性 Lewis 大鼠模型中促进轴突再生并防止视网膜神经纤维层退化[1]。
Elezanumab (0.01, 0.1, 1, 10 mg/kg; 静脉给药; 每周一次; 共 3 剂) 在脊柱靶向实验性自身免疫性脑脊髓炎 (EAE) 雌性 Lewis 大鼠模型中促进轴突再生和髓鞘再生，减少炎症病变面积并改善功能恢复[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Lewis rat optic neuritis models[1]
Dosage: 1, 3, or 10 mg/kg
Administration: IV; once a week for 5 doses
Result: Protected against the optic nerve inflammationinduced RNFL degeneration.
Showed significant protection of the RNFL, as demonstrated by decreased reduction in RNFL thickness measured by optical coherence tomography (OCT) with 10 mg/kg
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

依来努单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Elezanumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elezanumab1791416-49-3ABT-555 AE12-1Y-QL Anti-RGMA Reference Antibody (elezanumab)依来努单抗ABT555ABT 555TGF-beta/SmadTransforming growth factor betarepulsive guidance molecule ARGMaBMPSMAD1/5/8neuroregenerationneuroprotectionneuroregenerativeiron metabolismInhibitorinhibitorinhibit

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