2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. (-)-Pinoresinol 4-O-glucoside

(-)-Pinoresinol 4-O-glucoside  (Synonyms: (-)-Pinoresinol 4-O-β-D-glucopyranoside)

目录号: HY-N0946
产品使用指南

摩尔计算器

(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) 是一种有效的和具有口服活性的 α-glucosidase 抑制剂，IC50 值为 48.13 µM。(-)-Pinoresinol 4-O-glucoside 增加细胞迁移和前成骨细胞的早期分化。(-)-Pinoresinol 4-O-glucoside 增加 BMP2、p-Smad1/5/8、RUNX2 的蛋白质水平。(-)-Pinoresinol 4-O-glucoside 可减轻氧化应激、高血糖和肝毒性。(-)-Pinoresinol 4-O-glucoside 具有研究骨质疏松和牙周病的潜力。

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(-)-Pinoresinol 4-O-glucoside Chemical Structure

(-)-Pinoresinol 4-O-glucoside Chemical Structure

CAS No. : 41607-20-9

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(-)-Pinoresinol 4-O-glucoside 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease[1][2].

IC50 & Target

IC50: 48.13 µM (α-Glucosidase)[1]
体外研究
(In Vitro)

(-)-Pinoresinol 4-O-glucoside (0、10、30 µM；24 小时) 在含有 50 μg/mL 的成骨补充培养基 (OS) 中增加前成骨细胞分化过程中的细胞迁移[1]< /sup>.
(-)-Pinoresinol 4-O-glucoside (10、30 µM；7 天) 在前成骨细胞分化过程中增加早期分化并增加矿化结节的形成[1]。
(-)-Pinoresinol 4-O-glucoside (10、30 µM；3 天) 增加前成骨细胞中 BMP2、ALP、OCN mRNA 水平的表达[1]。
(-)-Pinoresinol 4-O-glucoside (10、30 µM；3 天) 增加 BMP2、p-Smad1/5/8、RUNX2 的蛋白表达水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Pinoresinol 4-O-glucoside 相关抗体:

RT-PCR[1]

Cell Line: pre-osteoblasts
Concentration: 10, 30 µM
Incubation Time: 3 days
Result: Upregulated the mRNA level of BMP2 and its target osteoblast genes, ALP and osteocalcin (OCN).

Western Blot Analysis[1]

Cell Line: pre-osteoblasts
Concentration: 10, 30 µM
Incubation Time: 3 days
Result: Enhanced protein level of BMP2, followed by the phosphorylation of Smad1/5/8 and the expression of RUNX2.
体内研究
(In Vivo)

(-)-Pinoresinol 4-O-glucoside (50 mg/kg；口服；20 天) 减轻小鼠的氧化应激、高血糖和肝毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 27-30 g, Male Swiss albino mice[2]
Dosage: 50 mg/kg
Administration: P.o.; twenty days
Result: Exhibited a hepatoprotective activity in vivo as it lowered AST and ALT levels, caused a prominent decline in serum glucose level by 37.83% in streptozotocin-treated mice with promising elevation in insulin level of 25.37%.
分子量

520.53

Formula

C26H32O11
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(-)-Pinoresinol 4-O-glucoside 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Pinoresinol 4-O-glucoside41607-20-9(-)-Pinoresinol 4-O-β-D-glucopyranosideGlucosidasepre-osteoblastsmigrationoxidative stresshyperglycemiahepatic toxicityosteoporosisInhibitorinhibitorinhibit

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