2. Gene
  3. Nek2 - NIMA (never in mitosis gene a)-related expressed kinase 2 Gene

Nek2 - NIMA (never in mitosis gene a)-related expressed kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 18005 | 基因类型: protein coding

关于 Nek2

功能概要

Enables protein kinase activity. Acts upstream of or within several processes, including blastocyst development; mitotic nuclear division; and negative regulation of DNA binding activity. Located in condensed nuclear chromosome; midbody; and spindle pole. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and respiratory system. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Nek2 基因产物(2)

mRNA Protein Name
NM_010892.3 NP_035022.2 serine/threonine-protein kinase Nek2
NM_010892.3 NP_035022.2 serine/threonine-protein kinase Nek2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14668482 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
14668482 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within blastocyst development IMP
IMP: 通过突变表型推断
19117032 MGI
acts upstream of or within chromosome segregation IMP
IMP: 通过突变表型推断
19117032 MGI
acts upstream of or within mitotic sister chromatid segregation IMP
IMP: 通过突变表型推断
15479717 MGI
acts upstream of or within mitotic spindle assembly IMP
IMP: 通过突变表型推断
19117032 MGI
acts upstream of or within negative regulation of DNA binding IDA
IDA: 通过直接分析推断
14668482 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
14697346 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in condensed nuclear chromosome IDA
IDA: 通过直接分析推断
15479717 MGI
located in midbody IDA
IDA: 通过直接分析推断
15479717 MGI
located in spindle pole IDA
IDA: 通过直接分析推断
15479717 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine/threonine-protein kinase Nek2

NIMA - related expressed kinase 2

NIMA-related expressed kinase 2

NIMA-related kinase 2

Nek2 kinase

never in mitosis A-related kinase 2

nimA-related protein kinase 2

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-120356A T-1101 tosylate Inhibitor 98.91% Phase 1
Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-117154 INH154 99.89% 否
HY-101029 MBM-55 Inhibitor 99.94% 否
HY-16660 INH1 Inhibitor 99.85% 否
HY-116423 JH295 98.66% 否
HY-156437 NBI-961 Inhibitor 99.73% 否
HY-100541 INH6 Inhibitor 99.53% 否
HY-101030A MBM-17S Inhibitor / 否
HY-B0790 TAI-1 Inhibitor 98.02% 否
HY-137046 Nek2-IN-4 / 否
HY-116423A JH295 hydrate ≥99.0% 否
HY-153749 Nek2/Hec1-IN-2 ≥98.0% 否
HY-101030 MBM-17 Inhibitor / 否
HY-101029A MBM-55S Inhibitor / 否
HY-120356 T-1101 Inhibitor / 否
HY-150046 Nek2-IN-6 / 否
HY-120330 Nek2-IN-5 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nek2 NCBI NCBI:4751
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