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JH295 hydrate 

目录号: HY-116423A
产品使用指南

JH295 hydrate 是一种有效,不可逆和选择性的 NIMA-related kinase 2 (Nek2) 抑制剂,IC50 为 770 nM。JH295 hydrate 通过 Cys22 的烷基化抑制细胞 Nek2。JH295 hydrate 对有丝分裂激酶 Cdk1,Aurora B 或 Plk1 没有活性,并且不会干扰双极纺锤体组件或纺锤体组件检查点。

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JH295 hydrate Chemical Structure

JH295 hydrate Chemical Structure

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Description

JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint[1].

IC50 & Target

IC50: 770 nM (Nek2)[1]

In Vitro

JH295 (Compound 16; 0.08-20 μM; 45 minutes; RPMI7951 cells) treatment inhibits WT Nek2 in cells with an IC50 of ~1.3 μM, whereas it has little effect on the C22V mutant[1].

Western Blot Analysis[1]

Cell Line: RPMI7951 cells
Concentration: 0.08 μM, 0.25 μM, 0.74 μM, 2.2 μM, 6.6 μM, 20 μM
Incubation Time: 45 minutes
Result: Inhibited WT Nek2 in cells with an IC50 of ~1.3 μM, whereas had little effect on the C22V mutant.
Molecular Weight

338.36

Formula

C₁₈H₁₈N₄O₃

SMILES

C#CC(NC1=CC2=C(NC(/C2=C\C3=C(C)N=C(CC)N3)=O)C=C1)=O.[H]O[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

JH295JH 295JH-295OthersNek2centrosomalCys22propynamidecellularalkylationcell-permeableInhibitorinhibitorinhibit

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产品名称:
JH295 hydrate
目录号:
HY-116423A
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