2. Gene
  3. NEK2 - NIMA related kinase 2 Gene

NEK2 - NIMA related kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NIMA 相关激酶 2

种属: Homo sapiens

同用名: NLK1; RP67; NEK2A; HsPK21; PPP1R111

基因 ID: 4751 | 基因类型: protein coding

关于 NEK2

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,658,256-211,675,621 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues, 8 paralogues and is associated with 3 phenotypes. Biased expression in testis (RPKM 28.1), bone marrow (RPKM 3.8) and 6 other tissues.

功能概要

该基因编码参与有丝分裂调节的丝氨酸/苏氨酸蛋白激酶。这种蛋白质定位于中心体，在 G1 期检测不到，但在整个 S 期逐渐积累，在 G2 后期达到最大水平。编码具有不同 C 末端的不同亚型的选择性剪接转录物变体已被注意到该基因。[RefSeq 提供，2011 年 2 月]

This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]

NEK2 基因产物(3)

mRNA Protein Name
NM_001204182.2 NP_001191111.1 serine/threonine-protein kinase Nek2 isoform 3
NM_001204183.2 NP_001191112.1 serine/threonine-protein kinase Nek2 isoform 2
NM_002497.4 NP_002488.1 serine/threonine-protein kinase Nek2 isoform 1

NEK2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (8 - 270)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase Nek2

NIMA (never in mitosis gene a)-related kinase 2

关联疾病

疾病名称 别名
Retinitis Pigmentosa 67

RP67

Retinitis Pigmentosa, Type 67
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (15)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122639 ZINC05007751 Inhibitor 98.47% 否
HY-101029 MBM-55 Inducer 99.94% 否
HY-117154 INH154 Inhibitor 99.95% 否
HY-16660 INH1 Activator 99.85% 否
HY-100541 INH6 Activator 99.90% 否
HY-120356A T-1101 tosylate Activator 99.05% 否
HY-117884 (Rac)-CCT 250863 Inducer 99.50% 否
HY-137046 Nek2-IN-4 Inhibitor / 否
HY-101029A MBM-55S / 否
HY-101030 MBM-17 Activator / 否
HY-101030A MBM-17S Activator / 否
HY-150046 Nek2-IN-6 Inhibitor / 否
HY-153749 Nek2/Hec1-IN-2 ≥98.0% 否
HY-156437 NBI-961 / 否
HY-RS09193 NEK2 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NEK2 VGNC VGNC:75308
Mus musculus NEK2 MGD MGI:109359
Canis familiaris NEK2 VGNC VGNC:43731
Bos taurus NEK2 VGNC VGNC:31993
Felis catus NEK2 VGNC VGNC:68456
Rattus norvegicus NEK2 RGD RGD:619792
Others NEK2 NCBI
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