2. Gene
  3. Pten - phosphatase and tensin homolog Gene

Pten - phosphatase and tensin homolog Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸酶和张力蛋白同系物

种属: Mus musculus

同用名: TEP1; MMAC1; PTENbeta; 2310035O07Rik; A130070J02Rik; B430203M17Rik

基因 ID: 19211 | 基因类型: protein coding

关于 Pten

Chromosome 19: 32,734,897-32,803,560 forward strand.GRCm39:CM001012.3

This gene has 3 transcripts (splice variants), 139 orthologues, 5 paralogues and is associated with 117 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 14.6), cortex adult (RPKM 12.9) and 28 other tissues.

功能概要

该基因编码的磷酸酶对磷脂和蛋白质具有双重活性，可作为肿瘤抑制因子。该蛋白质包含四个结构域，一个 PIP2 结合域，一个催化张力蛋白型磷酸酶结构域，一个 C2 张力蛋白型结构域和一个 PDZ 结合域。该蛋白质属于蛋白质酪氨酸磷酸酶家族。小鼠中该基因的缺失有助于多个组织的肿瘤发生。 [RefSeq 提供，2015 年 9 月]

This gene encodes a Phosphatase with dual activity against Phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type Phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine Phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]

Pten 基因产物(1)

mRNA Protein Name
NM_008960.2 NP_032986.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IDA
IDA: 通过直接分析推断
9778245 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16456542 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
20940307 MGI
enables ubiquitin ligase activator activity IMP
IMP: 通过突变表型推断
21241890 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of B cell proliferation IMP
IMP: 通过突变表型推断
16027169 MGI
acts upstream of T cell proliferation IMP
IMP: 通过突变表型推断
16027169 MGI
involved in adult behavior IMP
IMP: 通过突变表型推断
16675393 MGI
acts upstream of or within angiogenesis IMP
IMP: 通过突变表型推断
16107612 MGI
acts upstream of or within apoptotic process IGI
IGI: 通过遗传相互作用推断
20418913 MGI
involved in brain morphogenesis IMP
IMP: 通过突变表型推断
19208814 MGI
acts upstream of or within cardiac muscle tissue development IMP
IMP: 通过突变表型推断
16107612 MGI
acts upstream of or within cell migration IMP
IMP: 通过突变表型推断
12091320 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
16027168 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
16027169 MGI
acts upstream of or within cellular response to decreased oxygen levels IDA
IDA: 通过直接分析推断
24875179 MGI
acts upstream of or within cellular response to hypoxia IDA
IDA: 通过直接分析推断
24875179 MGI
acts upstream of or within central nervous system development IMP
IMP: 通过突变表型推断
12091320 MGI
involved in central nervous system myelin maintenance IMP
IMP: 通过突变表型推断
18082964 MGI
involved in central nervous system neuron axonogenesis IMP
IMP: 通过突变表型推断
16675393 MGI
involved in dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
18082964 MGI
involved in dentate gyrus development IMP
IMP: 通过突变表型推断
17706614 MGI
acts upstream of or within endothelial cell migration IMP
IMP: 通过突变表型推断
16107612 MGI
involved in forebrain morphogenesis IMP
IMP: 通过突变表型推断
16675393 MGI
acts upstream of or within gene expression IGI
IGI: 通过遗传相互作用推断
20418913 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
15755804 MGI
involved in learning or memory IMP
IMP: 通过突变表型推断
16675393 MGI
involved in locomotor rhythm IMP
IMP: 通过突变表型推断
17706614 MGI
involved in locomotory behavior IMP
IMP: 通过突变表型推断
16675393 MGI
involved in long-term synaptic potentiation IMP
IMP: 通过突变表型推断
18082964 MGI
involved in male mating behavior IMP
IMP: 通过突变表型推断
16675393 MGI
involved in maternal behavior IMP
IMP: 通过突变表型推断
16675393 MGI
involved in multicellular organismal response to stress IMP
IMP: 通过突变表型推断
16675393 MGI
acts upstream of myelination IMP
IMP: 通过突变表型推断
20448149 MGI
acts upstream of or within negative regulation of B cell proliferation IMP
IMP: 通过突变表型推断
16027169 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: 通过突变表型推断
16027169 MGI
acts upstream of or within negative regulation of TORC1 signaling IMP
IMP: 通过突变表型推断
29057879 MGI
acts upstream of or within negative regulation of androgen receptor signaling pathway IMP
IMP: 通过突变表型推断
29057879 MGI
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
10339565 MGI
involved in negative regulation of axon regeneration IMP
IMP: 通过突变表型推断
26203138 MGI
involved in negative regulation of axonogenesis IMP
IMP: 通过突变表型推断
16675393 MGI
involved in negative regulation of cardiac muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
23575307 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
16027168 MGI
involved in negative regulation of cell size IMP
IMP: 通过突变表型推断
21411674 MGI
involved in negative regulation of cellular senescence IMP
IMP: 通过突变表型推断
21241890 MGI
involved in negative regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
16675393 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
15994948 MGI
involved in negative regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
21411674 MGI
acts upstream of or within negative regulation of myelination IMP
IMP: 通过突变表型推断
20448149 MGI
involved in negative regulation of organ growth IMP
IMP: 通过突变表型推断
19208814 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
20448149 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
10339565 MGI
acts upstream of or within negative regulation of protein kinase activity by regulation of protein phosphorylation IGI
IGI: 通过遗传相互作用推断
20418913 MGI
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
19147652 MGI
involved in negative regulation of ribosome biogenesis IMP
IMP: 通过突变表型推断
18082964 MGI
involved in negative regulation of synaptic vesicle clustering IMP
IMP: 通过突变表型推断
16675393 MGI
involved in neuron-neuron synaptic transmission IMP
IMP: 通过突变表型推断
18082964 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
20448149 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
25512490 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IMP
IMP: 通过突变表型推断
9778245 MGI
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
21241890 MGI
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
18082964 MGI
involved in postsynaptic density assembly IMP
IMP: 通过突变表型推断
18082964 MGI
involved in prepulse inhibition IMP
IMP: 通过突变表型推断
16675393 MGI
involved in presynaptic membrane assembly IMP
IMP: 通过突变表型推断
18082964 MGI
acts upstream of or within prostate gland growth IMP
IMP: 通过突变表型推断
15994948 MGI
acts upstream of or within regulation of B cell apoptotic process IMP
IMP: 通过突变表型推断
9990064 MGI
acts upstream of or within regulation of axon regeneration IGI
IGI: 通过遗传相互作用推断
24733831 MGI
acts upstream of or within regulation of cell cycle IGI
IGI: 通过遗传相互作用推断
18332125 MGI
involved in regulation of cellular component size IMP
IMP: 通过突变表型推断
18082964 MGI
involved in regulation of cellular localization IMP
IMP: 通过突变表型推断
21266327 MGI
acts upstream of or within regulation of macrophage apoptotic process IMP
IMP: 通过突变表型推断
9990064 MGI
involved in regulation of neuron projection development IMP
IMP: 通过突变表型推断
19778506 MGI
acts upstream of or within regulation of synaptic transmission, GABAergic IMP
IMP: 通过突变表型推断
24875179 MGI
involved in rhythmic synaptic transmission IMP
IMP: 通过突变表型推断
17706614 MGI
involved in social behavior IMP
IMP: 通过突变表型推断
16675393 MGI
involved in synapse assembly IMP
IMP: 通过突变表型推断
16675393 MGI
involved in synapse maturation IMP
IMP: 通过突变表型推断
18082964 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Schmidt-Lanterman incisure IDA
IDA: 通过直接分析推断
20237282 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
14522255 MGI
located in myelin sheath adaxonal region IDA
IDA: 通过直接分析推断
20237282 MGI
is active in neuron projection IDA
IDA: 通过直接分析推断
21664258 MGI
located in neuron projection IMP
IMP: 通过突变表型推断
21664258 MGI
located in nucleus IDA
IDA: 通过直接分析推断
14522255 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pten 蛋白结构

PTP_PTEN

PTP_PTEN: cd14509 (23 - 180)

PTEN_C2

PTEN_C2: pfam10409 (187 - 348)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
蛋白主名 其他名称

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

PTENepsilon

mitochondrial PTENalpha

mutated in multiple advanced cancers 1

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-128932 Cefminox sodium 99.83% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-106263B Tyroserleutide hydrochloride Activator 99.98% Phase 3
Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13074 VO-Ohpic trihydrate Inhibitor 98.0% 否
HY-15842 SF1670 Inhibitor 98.57% 否
HY-128693 BpV(HOpic) Inhibitor ≥98.0% 否
HY-N1435 Oroxin B Activator 99.39% 否
HY-N0103 Sophocarpine Activator 99.85% 否
HY-N1441 Afzelin 99.62% 否
HY-160093 SQLE-IN-1 Inducer 98.15% 否
HY-N2116 Ginkgolic acid C17:1 Inhibitor 99.80% 否
HY-122818 BpV(phen) trihydrate Inhibitor 98.0% 否
HY-144707 AK-778-XXMU Agonist 99.96% 否
HY-136065 bpV(phen) Inhibitor 98.0% 否
HY-18764 BpV(pic) potassium hydrate Inhibitor 98.8% 否
HY-170791 CIB-L43 Activator 99.71% 否
HY-N2993 Polyporenic acid C Activator 99.80% 否
HY-N8884 Coelonin Inhibitor 98.0% 否
HY-110067 VO-OHPic Inhibitor / 否
HY-131549A bpV(bipy) hydrate Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pten NCBI NCBI:5728
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