1. PI3K/Akt/mTOR Apoptosis Autophagy
  2. PTEN Apoptosis Autophagy
  3. VO-OHPic

VO-OHPic 是一种可逆的、非竞争性的、选择性的 PTEN 抑制剂,IC50 为 46 nM。在 doxorubicin 诱导的心肌病中,VO-OHPic 可减少细胞凋亡 (apoptosis)、不良的心脏重塑和促炎 M1 巨噬细胞。VO-OHPic 抑制细胞自噬 (autophagy)。

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VO-OHPic Chemical Structure

VO-OHPic Chemical Structure

CAS No. : 675848-25-6

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VO-OHPic 的其他形式现货产品:

Customer Review

Other Forms of VO-OHPic:

MCE 顾客使用本产品发表的 29 篇科研文献

WB

    VO-OHPic purchased from MCE. Usage Cited in: Redox Biol. 2019 Jan;20:390-401.  [Abstract]

    Western analysis of related genes expression in mice with the treatment of TAC, TAC+RES, and TAC+RES+VO-Ophic.

    VO-OHPic purchased from MCE. Usage Cited in: Redox Biol. 2019 Jan;20:390-401.  [Abstract]

    Immunoblotting analysis show that RES treatment markedly inhibited Ang II-induced degradation of PTEN, activation of AKT and mTOR and inactivation of AMPK, but this effect is reversed by VO-OHpic.

    VO-OHPic purchased from MCE. Usage Cited in: Redox Biol. 2019 Jan;20:390-401.  [Abstract]

    Immunoblotting analysis show that RES treatment markedly inhibited Ang II-induced degradation of PTEN, activation of AKT and mTOR and inactivation of AMPK, but this effect is reversed by VO-OHpic.

    VO-OHPic purchased from MCE. Usage Cited in: Stem Cell Res Ther. 2019 Jul 29;10(1):217.  [Abstract]

    Western blot showing the levels of phosphorylated and non-phosphorylated PTEN, AKT, and mTOR proteins before and after VO-OHpic trihydrate treatment.

    VO-OHPic purchased from MCE. Usage Cited in: Mol Vis. 2018 Jul 23;24:485-494.  [Abstract]

    The miR-21 inhibitor promotes the expression of the PTEN protein and inhibits the expression of p-AKT, and VO-Ohpic trihydrate reverses the effect.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy[1][2][3].

    IC50 & Target

    IC50: 46 nM (PTEN)[1]

    分子量

    361.16

    Formula

    C12H10N2O8V

    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献
    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    VO-OHPic
    目录号:
    HY-110067
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