2. Gene
  3. Syp - synaptophysin Gene

Syp - synaptophysin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Syp1

基因 ID: 24804 | 基因类型: protein coding

关于 Syp

功能概要

Enables protein domain specific binding activity and syntaxin-1 binding activity. Involved in endocytosis; regulation of Opioid Receptor signaling pathway; and response to amyloid-beta. Located in several cellular components, including excitatory synapse; postsynaptic density; and synaptic vesicle membrane. Part of protein-containing complex. Is integral component of synaptic vesicle membrane. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to human SYP (synaptophysin). [provided by Alliance of Genome Resources, Apr 2022]

Syp 基因产物(1)

mRNA Protein Name
NM_012664.3 NP_036796.1 synaptophysin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SNARE binding IPI
IPI: 通过物理相互作用推断
19196426 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
11786535 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
11786535 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
8567678 RGD
enables syntaxin-1 binding IDA
IDA: 通过直接分析推断
7553862 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endocytosis IMP
IMP: 通过突变表型推断
17005904 RGD
involved in regulation of opioid receptor signaling pathway IDA
IDA: 通过直接分析推断
17005904 RGD
involved in response to amyloid-beta IEP
IEP: 通过表达模式推断
20847448 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in excitatory synapse IDA
IDA: 通过直接分析推断
19730411 RGD
located in neuron projection terminus IDA
IDA: 通过直接分析推断
11786535 RGD
located in neuron spine IDA
IDA: 通过直接分析推断
20083202 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
26595655 RGD
located in presynaptic active zone IDA
IDA: 通过直接分析推断
17310244 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
8567678 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
10908612 RGD
is active in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
3923488 RGD
located in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
23792689 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
12181340 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

synaptophysin

major synaptic vesicle protein p38

Syp 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Syp P07825 Itm2b Rattus norvegicus Q5XIE8
Anti Bait CoIP
29476059
种属内
Syp P07825 Oprm1 Rattus norvegicus P33535
Anti Tag CoIP
17005904
种属内
Syp P07825 Oprm1 Rattus norvegicus P33535
Y2H
17005904
种属内
Syp P07825 Oprm1 Rattus norvegicus P33535
Pull Down
17005904
种属间
Syp P07825 Srcin1 Mus musculus Q9QWI6-2
Anti Tag CoIP
18662323
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100693 SYP-5 Inhibitor 99.21% 否
HY-136356 Triclopyricarb Inhibitor / 否
HY-136915 Pyrisoxazole Inhibitor / 否
HY-RS14102 SYP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS16733 Ptpn11 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS20686 Syp Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS27197 Syp Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-17521 Flumorph Inhibitor 99.57% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Syp NCBI NCBI:6855
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