Ugt1a1 - UDP glucuronosyltransferase family 1 member A1 Gene

种属: Rattus norvegicus

同用名: Ugt1; Udpgt; UDPGT 1-1

基因 ID: 24861 | 基因类型: protein coding

关于 Ugt1a1

功能概要

Enables enzyme binding activity and glucuronosyltransferase activity. Involved in several processes, including biphenyl catabolic process; cellular glucuronidation; and cellular response to lipid. Located in endoplasmic reticulum. Part of cytochrome complex. Used to study Crigler-Najjar syndrome and bilirubin metabolic disorder. Biomarker of hyperthyroidism; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; female reproductive organ Cancer (multiple); and hepatitis B. Orthologous to human UGT1A1 (UDP glucuronosyltransferase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]

Ugt1a1 基因产物(1)

mRNA	Protein	Name
NM_012683.2	NP_036815.1	UDP-glucuronosyltransferase 1A1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IDA IDA: 通过直接分析推断	17965520	RGD
enables glucuronosyltransferase activity	IDA IDA: 通过直接分析推断	11829457	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in acute-phase response	IEP IEP: 通过表达模式推断	9737578	RGD
involved in animal organ regeneration	IEP IEP: 通过表达模式推断	16222444	RGD
involved in biphenyl catabolic process	IDA IDA: 通过直接分析推断	16006569	RGD
involved in cellular glucuronidation	IDA IDA: 通过直接分析推断	9224784	RGD
involved in cellular response to estradiol stimulus	IEP IEP: 通过表达模式推断	9327435	RGD
involved in cellular response to ethanol	IEP IEP: 通过表达模式推断	11412396	RGD
involved in cellular response to glucocorticoid stimulus	IEP IEP: 通过表达模式推断	10100302	RGD
involved in cellular response to hormone stimulus	IEP IEP: 通过表达模式推断	10100302	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	8632018	RGD
involved in flavonoid glucuronidation	IDA IDA: 通过直接分析推断	8806713	RGD
involved in liver development	IEP IEP: 通过表达模式推断	16310220	RGD
involved in response to ethanol	IEP IEP: 通过表达模式推断	11848303	RGD
involved in response to glucocorticoid	IEP IEP: 通过表达模式推断	11829457	RGD
involved in response to lipopolysaccharide	IEP IEP: 通过表达模式推断	19356101	RGD
involved in response to nutrient	IEP IEP: 通过表达模式推断	11299074	RGD
involved in response to organic cyclic compound	IEP IEP: 通过表达模式推断	11854140	RGD
involved in response to starvation	IEP IEP: 通过表达模式推断	9841869	RGD
involved in response to steroid hormone	IEP IEP: 通过表达模式推断	11086234	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	11829457	RGD
involved in xenobiotic glucuronidation	IDA IDA: 通过直接分析推断	8806713	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of cytochrome complex	IDA IDA: 通过直接分析推断	17965520	RGD
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	14561759	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

UDP-glucuronosyltransferase 1A1

B1	UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glycosyltransferase 1 family, polypeptide A1	UDP-glucuronosyltransferase 1 family member 1
UDP-glucuronosyltransferase 1-1	UGT1*1
UGT1-01	UGT1.1

相关产品

Approval

生物活性分子 (3)

目录号	产品名	作用方式	纯度	是否罕见病
HY-15592	Cabotegravir	Inhibitor	99.91%	否
HY-15592A	Cabotegravir sodium	Inhibitor	99.87%	否
HY-108292	Propacetamol hydrochloride		99.89%	否

Pre-clinical Phase

生物活性分子 (19)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N0372	Licochalcone A	Inducer	99.76%	否
HY-111832	1,2,3,6-Tetragalloylglucose	Inhibitor	99.08%	否
HY-160250	UGT1A1-IN-1		99.27%	否
HY-111539	BAY-1316957	Antagonist	99.73%	否
HY-124364	RO6889678		/	否
HY-135581	Raloxifene 6-glucuronide	Modulator	/	否
HY-135581S1	Raloxifene 6-glucuronide-d4 lithium	Modulator	/	否
HY-15592AS	Cabotegravir-d3 sodium		/	否
HY-170503	MAT2A-IN-20	Inhibitor	/	否
HY-N0372R	Licochalcone A (Standard)	Inducer	/	否
HY-RS15426	UGT1A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS15427	UGT1A10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS15429	UGT1A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS15430	UGT1A6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS15431	UGT1A7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS15432	UGT1A8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS16797	Ugt1a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS23238	Ugt1a1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-100319	UK-157147	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Ugt1a1	NCBI	NCBI:54658

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