2. Gene
  3. Glp1r - glucagon-like peptide 1 receptor Gene

Glp1r - glucagon-like peptide 1 receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Glip; RATGL1RCP

基因 ID: 25051 | 基因类型: protein coding

关于 Glp1r

功能概要

Enables G protein-coupled peptide receptor activity and peptide hormone binding activity. Involved in several processes, including cAMP-mediated signaling; learning or memory; and positive regulation of Insulin secretion. Located in plasma membrane. Is integral component of plasma membrane. Used to study hyperglycemia and hypertension. Biomarker of obesity. Orthologous to human GLP1R (glucagon like peptide 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Glp1r 基因产物(1)

mRNA Protein Name
NM_012728.2 NP_036860.2 glucagon-like peptide 1 receptor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled peptide receptor activity IPI
IPI: 通过物理相互作用推断
8612565 RGD
enables glucagon-like peptide 1 receptor activity IDA
IDA: 通过直接分析推断
7527026 RGD
enables peptide hormone binding IDA
IDA: 通过直接分析推断
1326760 RGD
enables peptide receptor activity IDA
IDA: 通过直接分析推断
15789279 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
8612565 RGD
involved in associative learning IDA
IDA: 通过直接分析推断
12925848 RGD
involved in cAMP/PKA signal transduction IMP
IMP: 通过突变表型推断
10446905 RGD
involved in feeding behavior IMP
IMP: 通过突变表型推断
10933308 RGD
involved in hormone secretion IDA
IDA: 通过直接分析推断
8828468 RGD
involved in insulin secretion IMP
IMP: 通过突变表型推断
10362617 RGD
involved in learning or memory IMP
IMP: 通过突变表型推断
12925848 RGD
involved in memory IDA
IDA: 通过直接分析推断
12925848 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
12409292 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
12925848 RGD
NOT involved in positive regulation of D-glucose import IDA
IDA: 通过直接分析推断
12093887 RGD
involved in positive regulation of blood pressure IDA
IDA: 通过直接分析推断
12093887 RGD
involved in positive regulation of cell differentiation IMP
IMP: 通过突变表型推断
10580413 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
10580413 RGD
involved in positive regulation of insulin secretion IDA
IDA: 通过直接分析推断
12093887 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
11845326 RGD
involved in regulation of calcium ion transport IMP
IMP: 通过突变表型推断
10446905 RGD
involved in release of sequestered calcium ion into cytosol IDA
IDA: 通过直接分析推断
15789279 RGD
involved in response to glucose IMP
IMP: 通过突变表型推断
11845326 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
21046358 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glucagon-like peptide 1 receptor

GLP-1 receptor

GLP-1-R

GLP-1R

pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

Glp1r 抗体

目录号 产品名 应用 反应物种
HY-P81160 GLP-1R Antibody WB, IHC-P, IHC-F, ICC/IF, FC Human, Mouse, Rat

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-114118 Semaglutide 99.84% 否
HY-114118A Semaglutide TFA 99.92% 否
HY-114118B Semaglutide acetate 99.92% 否
HY-P0119A Lixisenatide acetate Agonist 99.65% 否
Clinical Phase
生物活性分子 (10)
目录号 产品名 作用方式
纯度 Phase
HY-112185 Orforglipron Agonist 99.64% Phase 3
HY-P4146 Survodutide Agonist 99.92% Phase 3
HY-P4146A Survodutide TFA Agonist 99.39% Phase 3
HY-P0165B Taspoglutide acetate Agonist / Phase 3
HY-P3375A Mazdutide TFA Agonist / Phase 3
HY-P3506B Retatrutide acetate Agonist / Phase 3
HY-P0264A Exendin(9-39) amide acetate Antagonist / Phase 3
HY-125824 Danuglipron Agonist 99.85% Phase 2
HY-153865 Lotiglipron Agonist 99.68% Phase 2
HY-P10018 Bamadutide Agonist 99.96% Phase 2
Pre-clinical Phase
生物活性分子 (83)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P3506 Retatrutide Agonist 99.96% 否
HY-121835 GLP-1R agonist 2 Agonist 99.94% 否
HY-P3375 Mazdutide Agonist 99.74% 否
HY-101116 GLP-1R Antagonist 1 Antagonist 99.67% 否
HY-P3506A Retatrutide TFA Agonist 99.10% 否
HY-114118F Semaglutide, FITC labeled 99.83% 否
HY-P3291 Dapiglutide Agonist 99.40% 否
HY-142162 LSN3318839 Modulator 99.81% 否
HY-45894 tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu Control 97.59% 否
HY-143312 V-0219 Modulator 99.86% 否
HY-112185A Orforglipron hemicalcium hydrate Agonist 99.71% 否
HY-116819 VU0453379 Modulator ≥98.0% 否
HY-141839 GLP-1R modulator C16 Modulator 99.60% 否
HY-141840 GLP-1R modulator C5 Modulator 99.60% 否
HY-141842 GLP-1R modulator L7-028 Modulator 98.77% 否
HY-112679 GLP-1 receptor agonist 2 Agonist 98.18% 否
HY-143312A V-0219 hydrochloride Modulator 99.65% 否
HY-148212 GLP-1R agonist 17 Agonist 99.82% 否
HY-P10302A GLP-1R/GIPR agonist-1 (soduim) Agonist 96.55% 否
HY-143312E (S)-V-0219 hydrochloride Modulator 99.71% 否
HY-144035 GLP-1R agonist 4 Agonist 99.77% 否
HY-143312D (R)-V-0219 hydrochloride Modulator 99.37% 否
HY-144034 GLP-1R agonist 3 Agonist 99.15% 否
HY-147625 GLP-1R agonist 12 Agonist 95.06% 否
HY-P10019 Pegsebrenatide Agonist 95.50% 否
HY-116819A VU0453379 hydrochloride Modulator ≥99.0% 否
HY-147623 GLP-1R agonist 10 Agonist 98.99% 否
HY-153193 LSN3160440 Modulator / 否
HY-163996 DD202-114 Agonist 98.47% 否
HY-114118S3 Semaglutide-13C6,15N TFA 96.04% 否
HY-P10716 Exendin-P5 Activator 96.70% 否
HY-108795B [Gly8]-GLP-1(7-37) acetate Agonist 99.11% 否
HY-145632 Pemvidutide Agonist / 否
HY-147622 GLP-1R agonist 9 Agonist / 否
HY-P10302 GLP-1R/GIPR agonist-1 Agonist / 否
HY-138996 GLP-1 receptor agonist 8 Agonist / 否
HY-172811 DA-302168S Agonist / 否
HY-120828 Albenatide Agonist / 否
HY-129657 GLP-1 receptor agonist 4 Agonist / 否
HY-143312B (R)-V-0219 Modulator / 否
HY-143312C (S)-V-0219 Modulator / 否
HY-144033 GLP-1R agonist 1 Agonist / 否
HY-144133 GLP-1R agonist 5 Agonist / 否
HY-144134 GLP-1R agonist 6 Agonist / 否
HY-144135 GLP-1R agonist 7 Agonist / 否
HY-144136 GLP-1R agonist 8 Agonist / 否
HY-145632A Pemvidutide TFA Antagonist 98.07% 否
HY-147626 GLP-1R agonist 13 Agonist / 否
HY-147627 GLP-1R agonist 14 Agonist / 否
HY-147628 GLP-1R agonist 15 Agonist / 否
HY-147629 GLP-1R agonist 16 Agonist / 否
HY-160031 GLP-1R agonist 19 Agonist / 否
HY-161915 GLP-1R agonist 23 Agonist / 否
HY-162306 GLP-1R agonist 18 Agonist / 否
HY-162435 GLP-1R agonist 20 Agonist / 否
HY-162436 GLP-1R agonist 21 Agonist / 否
HY-162437 GLP-1R agonist 22 Agonist / 否
HY-162979 GLP-1R agonist 25 Agonist / 否
HY-168481 GLP-1R agonist 27 Agonist / 否
HY-171850 GLP-1R modulator-1 Agonist / 否
HY-171851 GLP-1R agonist 32 Agonist / 否
HY-172410 GLP-1R agonist 28 Agonist / 否
HY-172673 GLP-1R agonist 31 Agonist / 否
HY-172836S GLP-1 receptor agonist 17-d3 Agonist / 否
HY-173479 GLP-1R agonist 30 Agonist / 否
HY-176493 GLP-1R agonist 33 Agonist / 否
HY-176770 GLP-1R agonist 34 Agonist / 否
HY-P10337 OXM-7 Agonist / 否
HY-P10842 d-GLP-2 E33A Agonist / 否
HY-P11043 GEP44 / 否
HY-P11044 GEP12 Agonist / 否
HY-P3539 Exendin-4 (3-39) / 否
HY-P3542 Des His1, Glu8 Exendin-4 Antagonist / 否
HY-P4386 (Asp28)-Exenatide Agonist / 否
HY-P5161 FC382K10W15 Agonist / 否
HY-P5161A FC382K10W15 TFA Agonist / 否
HY-RS05490 GLP1R Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-125824A Danuglipron tromethamine Agonist / 否
HY-142162A (S,R)-LSN3318839 Control / 否
HY-168585 GLP-1R agonist 26 Agonist / 否
HY-172411 GLP-1R agonist 29 Agonist / 否
HY-RS16631 Glp1r Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23066 Glp1r Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990013 Gulgafafusp alfa Inhibitor / 否
HY-P991099 Anti-GLP1R Antibody Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Glp1r NCBI NCBI:2740
Mus musculus Glp1r NCBI NCBI:14652
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