2. Gene
  3. Gpc3 - glypican 3 Gene

Gpc3 - glypican 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: OCI-5

基因 ID: 25236 | 基因类型: protein coding

关于 Gpc3

功能概要

Predicted to enable peptidyl-dipeptidase inhibitor activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Is anchored component of plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1 and nephroblastoma. Orthologous to human GPC3 (glypican 3). [provided by Alliance of Genome Resources, Apr 2022]

Gpc3 基因产物(1)

mRNA Protein Name
NM_012774.2 NP_036906.2 glypican-3 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
15537637 RGD
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway IDA
IDA: 通过直接分析推断
15537637 RGD
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
IGI: 通过遗传相互作用推断
15537637 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
7487896 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glypican-3

defective in Simpson-Golabi-Behmel overgrowth syndrome

intestinal protein OCI-5

proteoglycan GPC3

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99013 Codrituzumab Inhibitor 99.07% Phase 2
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153360 MC-GGFG-AM-(10Me-11F-Camptothecin) Inhibitor 98.99% 否
HY-P10888A GPC3 targeting peptide 1 TFA / 否
HY-RS05628 GPC3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-P10888 GPC3 targeting peptide 1 / 否
HY-RS16630 Gpc3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23065 Gpc3 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990840 Anti-GPC3 Antibody (YP7) Inhibitor ≥95.0% 否
HY-P990841 Anti-pan-Glypican Antibody (HS20) Inhibitor / 否
HY-P991448 MDX-1414 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gpc3 NCBI NCBI:2719
Macaca fascicularis Gpc3 NCBI NCBI:102137748
Mus musculus Gpc3 NCBI NCBI:14734
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