2. Immunology/Inflammation
  3. Glycoprotein VI
  4. Anti-GPC3 Antibody (YP7)

Anti-GPC3 Antibody (YP7) 

目录号: HY-P990840 纯度: ≥95.0%
COA 技术支持

Anti-GPC3 Antibody (YP7) 是一种小鼠 IgG1 κ 嵌合抗体，靶向人 GPC3。Anti-GPC3 Antibody (YP7) 与细胞表面相关蛋白聚糖-3 (GPC3) 的 C 端结构域发生反应。Anti-GPC3 Antibody (YP7) 可用于癌症的研究，如肝细胞癌 (HCC)。

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Anti-GPC3 Antibody (YP7)

Anti-GPC3 Antibody (YP7) Chemical Structure

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     可免费申领三个不同产品的试用装。

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1 mg ￥2000
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Anti-GPC3 Antibody (YP7) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-GPC3 Antibody (YP7) is a kind of mouse IgG1 κ chimeric antibody, targeting to human GPC3. Anti-GPC3 Antibody (YP7) reacts with the C-lobe of cell surface-associated glypican-3 (GPC3). Anti-GPC3 Antibody (YP7) can be used for the research of cancer, such as hepatocellular carcinoma (HCC)[1][2].

同型

Mouse IgG1 kappa
反应种属

Human
IC50 & Target

GPC3
体外研究
(In Vitro)

Anti-GPC3 Antibody (YP7) (1 μg/mL) 对肝细胞癌 (HCC) 和其他表达 GPC3 的癌症中 GPC3 的天然形式具有优异的结合亲和力和特异性[1]。
Anti-GPC3 Antibody (YP7) (IR700-YP7, IR700 and YP7 conjugation) (10 μg/mL, 6 h) 可诱导 A431/G1 细胞中的溶酶体肿胀、出芽和破裂[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-GPC3 Antibody (YP7) 相关抗体:
体内研究
(In Vivo)

Anti-GPC3 Antibody (YP7) (5 mg/kg，静脉注射，每周两次，持续两周) 可抑制负荷 HepG2 肿瘤的 BALB/c 裸鼠中的肿瘤生长[1]。
Anti-GPC3 Antibody (YP7) (IR700-YP7，IR700 与 YP7 偶联物) (100 μg，静脉注射) 联合近红外光照射可抑制 A431/G1 肿瘤小鼠 (纯合子无胸腺裸鼠) 中的肿瘤生长[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HepG2 tumor mice models (4-6 weeks, female, BALB/c nu/nu mice)[1]
Dosage: 5 mg/kg
Administration: Intravenously injection, twice a week for 2 weeks
Result: Inhibited tumor growth.
基因 ID

14734  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-GPC3 Antibody (YP7) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-GPC3 Antibody (YP7)Glycoprotein VIGPVIGPC3Hepatocellular carcinomaA431/G1HepG2Inhibitorinhibitorinhibit

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