2. Gene
  3. Smo - smoothened, frizzled class receptor Gene

Smo - smoothened, frizzled class receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：光滑的，卷曲的类受体

种属: Rattus norvegicus

同用名: Smoh

基因 ID: 25273 | 基因类型: protein coding

关于 Smo

Primary_assembly 4: 58,343,529-58,373,829 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 204 orthologues, 15 paralogues and is associated with 46 phenotypes. Biased expression in Uterus (RPKM 82.7), Kidney (RPKM 58.7) and 9 other tissues.

功能概要

预计该基因编码的蛋白可启动修补绑定活动。参与多个过程，包括神经元投射发育；成骨细胞增殖；血管相关平滑肌细胞迁移的正向调节。位于多个细胞成分中，包括生长锥；神经细胞体；和突触后密度。用于研究巴雷特食管；食道腺癌；和大脑中动脉梗塞。高眼压症的生物标志物；胰腺炎;癌前肿瘤；和视觉性癫痫。该基因的人类直系同源物与基底细胞癌有关；肝细胞癌；胰腺癌;和胰腺导管癌。与人类 SMO（平滑的卷曲类受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable patched binding activity. Involved in several processes, including neuron projection development; osteoblast proliferation; and positive regulation of vascular associated smooth muscle cell migration. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Used to study Barrett's esophagus; esophagus adenocarcinoma; and middle cerebral artery infarction. Biomarker of ocular hypertension; pancreatitis; pre-malignant neoplasm; and visual epilepsy. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human Smo (smoothened, Frizzled class receptor). [provided by Alliance of Genome Resources, Apr 2022]

Smo 基因产物(1)

mRNA Protein Name
NM_012807.2 NP_036939.2 smoothened homolog precursor
蛋白主名 其他名称

smoothened homolog

smoothened protein

smoothened, frizzled family receptor

相关产品

Approval
生物活性分子 (6)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16582A Sonidegib Antagonist 99.91% 是
HY-16391 Glasdegib Inhibitor 99.31% 是
HY-16582 Sonidegib diphosphate Antagonist 99.73% 是
HY-B0877 Halcinonide Agonist 99.56% 否
HY-B0603 Fluticasone Agonist / 否
HY-16391A Glasdegib maleate Inhibitor / 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-16587 Saridegib Inhibitor 99.87% Phase 3
HY-13242 Taladegib Inhibitor 99.57% Phase 2
HY-13809 BMS-833923 Inhibitor 98.11% Phase 2
Pre-clinical Phase
生物活性分子 (41)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12848 SAG Agonist 99.79% 否
HY-17024 Cyclopamine Inhibitor 99.97% 否
HY-15108 Purmorphamine Activator 99.89% 否
HY-12848B SAG hydrochloride Agonist 99.63% 否
HY-100224 SANT-1 Antagonist 99.88% 否
HY-15483 DY131 Inhibitor 99.88% 否
HY-12848C SAG dihydrochloride Agonist / 否
HY-12316 20(S)-Hydroxycholesterol Activator 98.70% 否
HY-100535 KAAD-Cyclopamine Antagonist ≥96.0% 否
HY-12317 GSA-10 Agonist 98.01% 否
HY-13459 PF-5274857 Antagonist 98.89% 否
HY-N0836 Jervine Inhibitor 98.03% 否
HY-145387 MRT-81 Antagonist 98.87% 否
HY-18636 LEQ506 Inhibitor 98.15% 否
HY-N0247 Saikosaponin B1 Inhibitor 99.42% 否
HY-15412 HhAntag 98.70% 否
HY-100036 MK-4101 Antagonist 98.31% 否
HY-117407 ALLO-2 Antagonist 99.72% 否
HY-113965 CUR61414 Inhibitor 99.04% 否
HY-18287A MRT-83 hydrochloride Antagonist 99.60% 否
HY-108507 MRT-10 Antagonist 98.99% 否
HY-18287 MRT-83 Antagonist 99.27% 否
HY-15108G Purmorphamine (GMP) Agonist / 否
HY-12848A (Rac)-SAG Agonist / 否
HY-12848S SAG-d3 Inhibitor 99.85% 否
HY-108508 SMANT hydrochloride Inhibitor 99.90% 否
HY-147743 SMO-IN-1 Inhibitor / 否
HY-13459A PF-5274857 hydrochloride Antagonist / 否
HY-145918 MRT-14 Antagonist 98.91% 否
HY-147744 AZD7254 Inhibitor / 否
HY-153499 SMO-IN-4 Antagonist / 否
HY-150564 SMO-IN-2 Inhibitor 98.12% 否
HY-131016 IHR-Cy3 Antagonist / 否
HY-147670 TPB15 Inhibitor / 否
HY-150567 SMO-IN-3 Inhibitor / 否
HY-162372 Hedgehog IN-6 Inhibitor / 否
HY-162273 Antibacterial agent 189 / 否
HY-148440 RL-0070933 Modulator / 否
HY-12316R 20(S)-Hydroxycholesterol (Standard) Activator / 否
HY-120499 AZD8542 Antagonist / 否
HY-110240 IHR-1 Antagonist 98.05% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smo NCBI NCBI:6608
Mus musculus Smo NCBI NCBI:319757
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