Fluticasone  (Synonyms: 氟替卡松)

Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC₅₀ value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells^[1][2].

Fluticasone (0-10 μM, 2 h) inhibits U2OS cells growth with an EC₅₀ value of 99 nM^[2].
Fluticasone (10-1000 nM, 48 h) decreases HRV-induced mucin production and involves in modulation of SPDEF-regulated genes and extracellular ATP release^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fluticasone (1 mg/kg; intranasal dropping; 7 d) suppresses rhinovirus-induced airways inflammation in vivo but also impairs anti-viral immune responses and increases viral titres, leading to mucus hypersecretion^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

444.51

C₂₂H₂₇F₃O₄S

90566-53-3

氟替卡松

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Seidel P, et al. Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies. Respir Res. 2012 Oct 4. 13(1):90.  [Content Brief]

  [2]. Wang J, et al. Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A. 2010 May 18. 107(20):9323-8.  [Content Brief]

  [3]. Ying Wang, et al. Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells. Front. Cell. Infect. Microbiol., 2020 Jun.  [Content Brief]

  [4]. Singanayagam A, et al. Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. Lancet. 2015 Feb 26. 385(Suppl 1):S88.  [Content Brief]