1. Stem Cell/Wnt
  2. Smo
  3. 20(S)-Hydroxycholesterol

20(S)-Hydroxycholesterol (Synonyms: 20α-Hydroxycholesterol)

目录号: HY-12316 纯度: >98.0%
产品使用指南

20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) 是平滑 (smo) 癌蛋白的变构激活剂,在以 NIH3T3 细胞的基因转录报告实验中,激活 hedgehog (Hh) 信号通路的 EC50 值为 3 μM。

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20(S)-Hydroxycholesterol Chemical Structure

20(S)-Hydroxycholesterol Chemical Structure

CAS No. : 516-72-3

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Description

20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells[1][2].

IC50 & Target

EC50: 3 μM (hedgehog signaling pathway)[1]

Molecular Weight

402.65

Formula

C₂₇H₄₆O₂

CAS No.

516-72-3

SMILES

C[C@@]1([C@@]2([H])[C@@](C)(O)CCCC(C)C)[C@](CC2)([H])[C@@](CC=C3[C@@]4(CC[C@H](O)C3)C)([H])[C@]4([H])CC1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
20(S)-Hydroxycholesterol
目录号:
HY-12316
需求量:

20(S)-Hydroxycholesterol

Cat. No.: HY-12316