GAS6 - growth arrest specific 6 Gene

中文名称：生长停滞特异性 6

种属: Homo sapiens

同用名: AXSF; AXLLG

基因 ID: 2621 | 基因类型: protein coding

关于 GAS6

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,820,549-113,864,076 (from NCBI)

This gene has 5 transcripts (splice variants), 142 orthologues and 3 paralogues. Ubiquitous expression in lung (RPKM 64.9), endometrium (RPKM 57.7) and 24 other tissues.

功能概要

该基因编码一种含γ-羧基谷氨酸 (Gla) 的蛋白质，被认为参与刺激细胞增殖。该基因在许多癌症中经常过度表达，并被认为是不良预后标志物。蛋白质水平升高还与多种疾病状态相关，包括静脉血栓栓塞性疾病、系统性红斑狼疮、慢性肾衰竭和先兆子痫。[RefSeq 提供，2014 年 8 月]

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

GAS6 基因产物(1)

mRNA	Protein	Name
NM_000820.4	NP_000811.1	growth arrest-specific protein 6 precursor

GAS6 蛋白结构

Gla

FXa_inhibition

EGF_CA

Laminin_G_1

Laminin_G_2

0
200
400
600
678 a.a.

蛋白主名

其他名称

growth arrest-specific protein 6

AXL receptor tyrosine kinase ligand

重组 GAS6 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70470	GAS6 Protein, Human (HEK293, Fc)	Q14393 (A31-A678)	≥95%
HY-P70780	GAS6 Protein, Human (HEK293, His)	Q14393-2 (A31-A678)	≥95%
HY-P77668	GAS6 Protein, Human (400a.a, HEK293, Fc)	Q14393-2 (D279-A678)	≥95%
HY-P700724	GAS6 Protein, Human (630a.a, HEK293, His)	Q14393-2 (A49-A678)	≥95%

关联疾病

疾病名称

别名

Mesangial Proliferative Glomerulonephritis

Glomerulonephritis - Mesangial Proliferative	Mesangial Proliferative Gn
Mesangioproliferative Glomerulonephritis	Glomerulonephritis Mesangial Proliferative

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Vitamin K Deficiency Bleeding

Vitamin K Deficiency	Deficiency Of Vitamin K
Vitamin K	Vitamin K Deficiency Hemorrhagic Disease

Glomerulonephritis

Bright'S Disease

Ciliary Dyskinesia, Primary, 33

Primary Ciliary Dyskinesia 33	CILD33
Ciliary Dyskinesia, Primary, 33, Without Situs Inversus	Primary Ciliary Dyskinesia 33 Without Situs Inversus

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Parameningeal Embryonal Rhabdomyosarcoma

La Crosse Encephalitis

California Encephalitis	California Virus Encephalitis
Neuroinvasive California Encephalitis Virus Infection	Californian Encephalitis
Encephalitis, California	California Meningoencephalitis
California Encephalitis Virus Infection	California Encephalitis Virus Infection Neuroinvasive Disease
California Meningoencephalitis Virus Disease	California Serogroup Virus Neuroinvasive Disease
California Viral Encephalitis	Ce - [California Encephalitis]
Lac - [La Crosse Encephalitis]

Meckel Syndrome, Type 7

Meckel Syndrome 7	Nphp3-Related Meckel-Like Syndrome
MKS7	Goldston Syndrome
Meckel Syndrome Type 7	Meckel-Like Syndrome Type 1
Renal-Hepatic-Pancreatic Dysplasia-Dandy-Walker Cysts Syndrome	Renal Hepatic Pancreatic Dysplasia Dandy Walker Cyst
Renal-Hepatic-Pancreatic Dysplasia With Dandy-Walker Cyst	Meckel-Gruber Syndrome, Type 7
Dandy-Walker Cyst With Renal-Hepatic-Pancreatic Dysplasia

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99463	Batiraxcept	Inhibitor	96.40%	Phase 3
HY-P99161	Tilvestamab	Inhibitor	98.08%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-119039	RU-301	Inhibitor	99.44%	否
HY-124066	RU-302	Inhibitor	98.02%	否
HY-N2995	Poricoic acid A	Modulator	≥98.0%	否
HY-149092	Anticancer agent 109		/	否
HY-152075	AXL-IN-14	Inhibitor	/	否
HY-RS05285	GAS6 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	GAS6	MGD	MGI:95660
Bos taurus	GAS6	VGNC	VGNC:29261
Macaca mulatta	GAS6	VGNC	VGNC:72885
Canis familiaris	GAS6	VGNC	VGNC:41118
Felis catus	GAS6	VGNC	VGNC:62469
Rattus norvegicus	GAS6	RGD	RGD:61913
Macaca fascicularis	GAS6	NCBI
Others	GAS6	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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GAS6 - growth arrest specific 6 Gene

关于 GAS6

功能概要

GAS6 基因产物(1)

GAS6 蛋白结构

重组 GAS6 蛋白

关联疾病

直系同源

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GAS6 - growth arrest specific 6 Gene

关于 GAS6

功能概要

GAS6 基因产物(1)

GAS6 蛋白结构

重组 GAS6 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z