2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway
  3. TAM Receptor PI3K Akt p38 MAPK
  4. Batiraxcept

Batiraxcept  (Synonyms: AVB-500; AVB-S6-500)

目录号: HY-P99463 纯度: 99.91%
COA 技术支持

Batiraxcept (AVB-500；AVB-S6-500) 是一种选择性、可溶性 AXL 受体和 GAS6 抑制剂，靶向 GAS6-AXL 信号轴。Batiraxcept 无口服活性，无法通过血脑屏障。Batiraxcept 竞争性结合 GAS6 ((KD <1 nM)，阻止其与 AXL 受体酪氨酸激酶相互作用，从而抑制下游 PI3K/AKT 和 MAPK 信号通路，减少肿瘤细胞糖酵解、血管生成和转移潜力。Batiraxcept 在子宫内膜癌、胆管癌和卵巢癌等临床前模型中通过抑制肿瘤生长、侵袭和转移展现抗肿瘤活性。

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CAS No. : 2268717-61-7

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1 mg ￥6000
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5 mg ￥15000
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Batiraxcept 相关抗体

Top Publications Citing Use of Products

查看 TAM Receptor 亚型特异性产品:

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Axl Mer Tyro3

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Batiraxcept (AVB-500; AVB-S6-500) is a selective, soluble AXL receptor and GAS6 inhibitor that targets the GAS6-AXL signaling axis. Batiraxcept is orally inactive and does not cross the blood-brain barrier. Batiraxcept competitively binds to GAS6 ((KD <1 nM), preventing its interaction with the AXL receptor tyrosine kinase, thereby inhibiting downstream PI3K/AKT and MAPK signaling pathways, reducing tumor cell glycolysis, angiogenesis, and metastatic potential. Batiraxcept has demonstrated antitumor activity in preclinical models of endometrial, cholangiocarcinoma, and ovarian cancer by inhibiting tumor growth, invasion, and metastasis[1][2][3].

IC50 & Target

Axl

 

体外研究
(In Vitro)

Batiraxcept (2 μM；24 h) 抑制化疗耐药子宫内膜癌细胞 (ARK1、PUC198) 活力，并与 12.5 nM Paclitaxel (HY-B0015) 协同作用，减少糖酵解代谢物及 pAKT 信号[1]。
Batiraxcept (100 μg/mL；24 h) 在 Matrigel 侵袭和划痕实验中降低胆管癌细胞 (SNU1196、HUCCT1) 的侵袭和迁移能力[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Batiraxcept 相关抗体:

Cell Viability Assay[1]

Cell Line: ARK1, PUC198 (human endometrial cancer)
Concentration: 2 μM
Incubation Time: 24 h
Result: Showed a 40-60% reduction in viability compared to control, with synergistic effect when combined with Paclitaxel.
体内研究
(In Vivo)

Batiraxcept (30 mg/kg；腹腔注射；每周两次；4 周) 在小鼠子宫内膜癌 (ARK1 细胞) 异种移植模型中显著抑制肿瘤生长和转移，减少肿瘤体积，减少转移结节[1]。
Batiraxcept (50 mg/kg,100 mg/kg；腹腔注射；每 2 天 1 次；25 天) 在小鼠子宫内膜癌 (SNU1196 细胞) 异种移植模型中显著减少胆管肿瘤细胞在腹腔内的播散，且不会影响免疫缺陷小鼠的体重[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (female, 6-8 weeks old, 18-22 g), ARK1 cell-derived endometrial cancer xenograft model[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection (i.p.), twice weekly for 4 weeks, starting 1 week after tumor cell inoculation
Result: -Tumor Growth:
Tumor volume was measured by caliper every 3 days. At the end of the treatment, the average tumor volume in the Batiraxcept group was 60% smaller than that in the control group.
-Metastasis:
Lung metastasis was evaluated by counting the number of metastatic nodules after sacrifice. The number of metastatic nodules in the Batiraxcept group was reduced by 80% compared to the control group.
Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

93.85 kDa

同用名

AVB-500; AVB-S6-500

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [AXL (AXL receptor tyrosine kinase, ARK, JTK11, Tyro7, UFO)]2-IGHG1 Fc (Fragment constant)
纯度 & 产品资料
参考文献

Batiraxcept 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Batiraxcept2268717-61-7AVB-500 AVB-S6-500AVB500AVB 500TAM ReceptorPI3KAktp38 MAPKTyro3AxlMerPhosphoinositide 3-kinasePKBProtein kinase BGAS6clear cell renal cell carcinomacancerccRCCovarian cancerInhibitorinhibitorinhibit

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