2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor
  4. Tilvestamab

Tilvestamab  (Synonyms: BGB149)

目录号: HY-P99161 纯度: 98.08%
COA

摩尔计算器

Tilvestamab (BGB149) 是一种人源化抗 AXL 抗体，阻断 AXL 介导的细胞信号传导。Tilvestamab 在体外能显著抑制 Gas6 刺激诱导的 AXL 激活，并抑制 786-0-Luc RCC 细胞中下游 AXL 的磷酸化。Tilvestamab可用于癌症，尤其是 AXL 过度表达肾细胞癌的研究。

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Tilvestamab Chemical Structure

Tilvestamab Chemical Structure

CAS No. : 2226775-26-2

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1 mg ￥2800
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5 mg ￥7300
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Tilvestamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits Gas6-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas[1].

IC50 & Target

AXL[1].
体外研究
(In Vitro)

Tilvestamab (250 µM; 1 h) inhibits AXL phosphorylation in 786-0 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tilvestamab 相关抗体:

Cell Viability Assay[1]

Cell Line: 786-0-Luc cells (Gas6- induced; Gas6 is a well characterized AXL ligand)
Concentration: 250 µM
Incubation Time: 1 h (pre-treat)
Result: Drastically inhibited Gas6- induced AXL phosphorylation and decreased the level of pAKT.
体内研究
(In Vivo)

Tilvestamab (30 mg/kg; i.p.; twice a week) suppresses tumor growth by inhibiting AXL in orthotopic RCC model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c athymic nude mice (8-week-old; orthotopic RCC model)[1].
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; twice a week
Result: Significantly inhibited RCC growth down to about 1/3 of the volume.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.08%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Tilvestamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tilvestamab2226775-26-2BGB149BGB 149BGB-149TAM ReceptorTyro3AxlMerRCC786-0-Luc cellstumorcancerrenal cell carcinomaInhibitorinhibitorinhibit

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