GAS6 蛋白, Human (HEK293, His)

GAS6 Protein, a ligand for AXL, TYRO3, and MER receptors, influences diverse cellular processes. GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports hepatic regeneration, influences gonadotropin-releasing hormone neuron survival and migration, regulates platelet activation, and modulates thrombotic responses. In microbial infections, GAS6 acts as a bridge between virus envelope phosphatidylserine and TAM receptor tyrosine kinase Axl, facilitating viral entry in apoptotic mimicry. This multifunctional role extends to diverse viruses, such as Dengue, Vaccinia, ebolavirus, and marburgvirus. GAS6 Protein, Human (HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GAS6 Protein, Human (HEK293, His) is 648 a.a., with molecular weight of 80-90 kDa.

GAS6 是酪氨酸蛋白激酶受体 AXL、TYRO3 和 MER 的配体，参与多种细胞过程，包括细胞生长、存活、粘附和迁移。 GAS6/AXL 信号传导通过防止细胞凋亡，有助于酸性条件下内皮细胞的存活，促进人类自然杀伤细胞发育过程中的最佳细胞因子信号传导，在肝再生中发挥作用，影响促性腺激素释放激素神经元的存活和迁移，调节血小板活化，并调节血栓反应。此外，在微生物感染中，GAS6 可以充当病毒包膜磷脂酰丝氨酸和 TAM 受体酪氨酸激酶 Axl 之间的桥梁，通过凋亡拟态促进病毒进入。这种独特的功能延伸到它参与多种病毒的进入过程，包括登革热、痘苗病毒、埃博拉病毒和马尔堡病毒，突显了 GAS6 在细胞和感染环境中的多方面作用。

Human

HEK293

C-6*His

Q14393-2 (A31-A678)

2621  [NCBI]

ALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA

80-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.