2. Gene
  3. Skp2 - S-phase kinase-associated protein 2 Gene

Skp2 - S-phase kinase-associated protein 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: p45; FWD1; FBXL1; 4930500A04Rik

基因 ID: 27401 | 基因类型: protein coding

关于 Skp2

功能概要

Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including cellular protein metabolic process; mitotic cell cycle phase transition; and positive regulation of intracellular Estrogen receptor signaling pathway. Part of SCF ubiquitin Ligase complex. Is expressed in several structures, including blastocyst; compacted morula; and retina nuclear layer. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Skp2 基因产物(2)

mRNA Protein Name
NM_001285980.1 NP_001272909.1 S-phase kinase-associated protein 2 isoform c
NM_013787.3 NP_038815.1 S-phase kinase-associated protein 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17785450 MGI
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: 通过直接分析推断
22464731 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
10790373 MGI
acts upstream of or within G2/M transition of mitotic cell cycle IGI
IGI: 通过遗传相互作用推断
19056892 MGI
acts upstream of or within G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
19056892 MGI
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
22464731 MGI
acts upstream of or within positive regulation of intracellular estrogen receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
17785450 MGI
acts upstream of or within positive regulation of protein polyubiquitination IDA
IDA: 通过直接分析推断
23277542 MGI
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
22464731 MGI
acts upstream of or within protein polyubiquitination IDA
IDA: 通过直接分析推断
17785450 MGI
acts upstream of or within regulation of cell cycle IPI
IPI: 通过物理相互作用推断
10790373 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
10790373 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
19056892 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SCF ubiquitin ligase complex IDA
IDA: 通过直接分析推断
17785450 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

S-phase kinase-associated protein 2

F-box protein Skp2

F-box/WD-40 protein 1

cyclin A/CDK2-associated protein p45

相关产品

Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100237 SZL P1-41 99.07% 否
HY-16661 Skp2 Inhibitor C1 Inhibitor 98.21% 否
HY-N0704 Agrimol B 99.75% 否
HY-135199 Ubiquitination-IN-1 Inhibitor 99.84% 否
HY-112158 NSC139021 Inhibitor 99.86% 否
HY-148900 SCFSkp2-IN-2 Inhibitor 99.01% 否
HY-15694 SMIP004 99.79% 否
HY-123578 NSC689857 Inhibitor 99.49% 否
HY-153937 Skp2 inhibitor 2 Inhibitor 99.88% 否
HY-162938 Skp2 inhibitor 3 Inhibitor 98.07% 否
HY-W1128879 XMU-MP-8 Degrader / 否
HY-149954 SARS-CoV-2-IN-39 Inhibitor 99.79% 否
HY-174346 Skp2-IN-4 Inhibitor / 否
HY-RS12974 SKP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-P11020 p27 Analogue CP2 Inhibitor / 否
HY-RS15591 UXT Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16925 Skp2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23368 Skp2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Skp2 NCBI NCBI:6502
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