NT5C - 5', 3'-nucleotidase, cytosolic Gene

中文名称：5', 3'-核苷酸酶，胞质

种属: Homo sapiens

同用名: DNT; cdN; DNT1; P5N2; PN-I; HEL74; PN-II; UMPH2; dNT-1

基因 ID: 30833 | 基因类型: protein coding

关于 NT5C

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,130,228-75,131,742 (from NCBI)

This gene has 14 transcripts (splice variants), 115 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 12.8), spleen (RPKM 11.1) and 25 other tissues.

功能概要

该基因编码的核苷酸酶可催化 5' 脱氧核糖核苷酸 (dNTP) 和 2' (3') -dNTP 和核糖核苷酸的去磷酸化，但不会催化 5' 核糖核苷酸的去磷酸化。在表征的不同形式的核苷酸酶中，这种酶的独特之处在于其对 5'-dNTP 的偏好。它可能是参与调节细胞中 dNTP 池大小的酶之一。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2011 年 11 月]

This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the Enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

NT5C 基因产物(2)

mRNA	Protein	Name
NM_001252377.2	NP_001239306.1	5'(3')-deoxyribonucleotidase, cytosolic type isoform 2
NM_014595.3	NP_055410.1	5'(3')-deoxyribonucleotidase, cytosolic type isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	31515488	GOA
enables nucleotidase activity	IDA IDA: 通过直接分析推断	10681516	GOA
enables pyrimidine nucleotide binding	IDA IDA: 通过直接分析推断	10681516	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in dephosphorylation	IDA IDA: 通过直接分析推断	10681516	GOA
involved in pyrimidine deoxyribonucleotide catabolic process	IDA IDA: 通过直接分析推断	10681516	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10681516	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10681516	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NT5C 蛋白结构

NT5C

0
100
201 a.a.

蛋白主名

其他名称

5'(3')-deoxyribonucleotidase, cytosolic type

5' nucleotidase, deoxy (pyrimidine), cytosolic type C

NT5C 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NT5C	Q8TCD5	RAP1GDS1	Homo sapiens	P52306	Anti Tag CoIP	33961781
种属内	NT5C	Q8TCD5	NT5C	Homo sapiens	Q8TCD5	Validated Y2H	32296183
种属内	NT5C	Q8TCD5	RAP1GDS1	Homo sapiens	P52306	Anti Tag CoIP	28514442
种属内	NT5C	Q8TCD5	NT5C	Homo sapiens	Q8TCD5	Y2H Array	32296183
种属内	NT5C	Q8TCD5	NT5C	Homo sapiens	Q8TCD5	Y2H Array	31515488
种属内	NT5C	Q8TCD5	NT5C	Homo sapiens	Q8TCD5	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Trichostrongylosis

Trichostrongyliasis	Infection By Trichostrongylus
Infection By Trichostrongylus Species	Trichostrongylus Infestation

Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive	Autosomal Recessive Robinow Syndrome
Covesdem Syndrome	RRS1
Costovertebral Segmentation Defect-Mesomelia Syndrome	Rrs
Costovertebral Segmentation Defect With Mesomelia, Formerly	Covesdem Syndrome, Formerly
Costovertebral Segmentation Defect With Mesomelia	Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly	Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly	Robinow, Autosomal Recessive Syndrome, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-167710	CRCD2		99.02%	否
HY-RS09607	NT5C Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS09608	NT5C1A Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS09609	NT5C2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS16401	NT5C3A Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS19266	Nt5c1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21396	Nt5c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21673	Nt5c2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25755	Nt5c1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27683	Nt5c3a Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27915	Nt5c Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS28191	Nt5c2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	NT5C	VGNC	VGNC:99311
Mus musculus	NT5C	MGD	MGI:1354954
Canis familiaris	NT5C	VGNC	VGNC:43994
Bos taurus	NT5C	VGNC	VGNC:32289
Rattus norvegicus	NT5C	RGD	RGD:2321875
Macaca mulatta	NT5C	VGNC	VGNC:99191
Others	NT5C	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NT5C - 5', 3'-nucleotidase, cytosolic Gene

关于 NT5C

功能概要

NT5C 基因产物(2)

NT5C 蛋白结构

NT5C 蛋白互作信息

关联疾病

直系同源

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NT5C - 5', 3'-nucleotidase, cytosolic Gene

关于 NT5C

功能概要

NT5C 基因产物(2)

NT5C 蛋白结构

NT5C 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z