Gsdme - gasdermin E Gene

种属: Rattus norvegicus

同用名: Dfna5; Dfna5h

关于 Gsdme

功能概要

Predicted to enable cardiolipin binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and wide pore channel activity. Predicted to be involved in several processes, including cellular response to tumor necrosis factor; granzyme-mediated programmed cell death signaling pathway; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within inner ear receptor cell differentiation. Predicted to be located in cytosol and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 5 and sensorineural hearing loss. Orthologous to human GSDME (gasdermin E). [provided by Alliance of Genome Resources, Apr 2022]