2. Apoptosis Immunology/Inflammation
  3. Caspase Pyroptosis
  4. Ac-DMLD-CMK

Ac-DMLD-CMK 是一种靶向小鼠 caspase 3-Gsdme 信号通路的多肽。Ac-DMLD-CMK 可以特异性抑制 caspase 3 和 Gsdme 的激活。Ac-DMLD-CMK 阻断 caspase 3 对 Gsdme 的裂解，抑制焦亡的发生，从而减轻肾小管上皮细胞损伤和炎性细胞因子的分泌。Ac-DMLD-CMK 可降低 Cisplatin (HY-17394) 诱导的小鼠血清肌酐和血尿素氮水平，减轻肾功能恶化。Ac-DMLD-CMK 有望用于化疗药物致肾毒性的研究。

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Ac-DMLD-CMK Chemical Structure

Ac-DMLD-CMK Chemical Structure

CAS No. : 2588354-33-8

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Ac-DMLD-CMK 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ac-DMLD-CMK is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin (HY-17394) and alleviates the deterioration of kidney function. Ac-DMLD-CMK is promising for research of chemotherapy drug-induced nephrotoxicity[1].

IC50 & Target

Caspase 3

 

分子量

567.05

Formula

C22H35ClN4O9S
CAS 号
Sequence

Ac-Asp-Met-Leu-{Asp-CMK}
Sequence Shortening

Ac-DML-{Asp-CMK}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ac-DMLD-CMK 相关分类

  • 摩尔计算器

  • 稀释计算器

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-DMLD-CMK2588354-33-8CaspasePyroptosiscaspase 3-Gsdmepyroptosisinflammatory cytokinesnephrotoxicityInhibitorinhibitorinhibit

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产品名称：
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目录号：
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