2. Cell Cycle/DNA Damage Epigenetics Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. PARP Reactive Oxygen Species (ROS) Caspase Apoptosis Pyroptosis
  4. 4,4′-Secalonic acid D

4,4′-Secalonic acid D (Compound 12) 是一种 PARP1 抑制剂。4,4′-Secalonic acid D 通过抑制 PARP1，诱导 ROS 积累和 DNA 损伤，激活 caspase-3/GSDME 通路，引发肿瘤细胞凋亡 (apoptosis) 和焦亡 (pyroptosis)。4,4′-Secalonic acid D 具有抗肿瘤的活性。

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4,4′-Secalonic acid D

4,4′-Secalonic acid D Chemical Structure

CAS No. : 2265910-52-7

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4,4′-Secalonic acid D 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the caspase-3/GSDME pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
11.7 μM
Compound: 7
Cytotoxicity against human A549 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
HCT-116 IC50
0.5 μM
Compound: 7
Cytotoxicity against human HCT116 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
HL-60 IC50
0.9 μM
Compound: 7
Cytotoxicity against human HL60 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
K562 IC50
0.4 μM
Compound: 7
Cytotoxicity against human K562 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
MGC-803 IC50
0.9 μM
Compound: 7
Cytotoxicity against human MGC803 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human MGC803 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
NCI-H1975 IC50
3.5 μM
Compound: 7
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
分子量

638.57

Formula

C32H30O14
CAS 号
结构分类
初始来源

Paraconiothyrium sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4,4′-Secalonic acid D 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4,4′-Secalonic acid D2265910-52-7PARPReactive Oxygen Species (ROS)CaspaseApoptosisPyroptosispoly ADP ribose polymerase HepG2WRL68Inhibitorinhibitorinhibit

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