LTC4S - leukotriene C4 synthase Gene

中文名称：白三烯 C4 合酶

种属: Homo sapiens

基因 ID: 4056 | 基因类型: protein coding

关于 LTC4S

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,793,986-179,796,647 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 182 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in fat (RPKM 3.3), lung (RPKM 2.5) and 23 other tissues.

功能概要

MAPEG (花生酸和谷胱甘肽代谢中的膜相关蛋白) 家族包括许多人类蛋白质，其中一些与白三烯的产生有关。该基因编码一种酶，该酶催化半胱氨酰白三烯生物合成的第一步，这是源自花生四烯酸的有效生物化合物。白三烯被认为是过敏反应和炎症性疾病如人类支气管哮喘的介质。这种蛋白质定位于核膜和相邻的内质网。[RefSeq 提供，2008 年 7 月]

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an Enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]

LTC4S 基因产物(1)

mRNA	Protein	Name
NM_145867.2	NP_665874.1	leukotriene C4 synthase

LTC4S 蛋白结构

MAPEG

0
100
150 a.a.

蛋白主名

其他名称

leukotriene C4 synthase

LTC4 synthase

重组 LTC4S 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75919	LTC4S Protein, Human (sf9, His)	Q16873 (M1-A150)	≥95%

关联疾病

疾病名称

别名

Leukotriene C4 Synthase Deficiency

Ltc4 Synthase Deficiency

Hypotonia-Failure To Thrive-Microcephaly Syndrome

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Aspirin-Induced Respiratory Disease

Aspirin-Sensitive Asthma

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Asthma, Nasal Polyps, And Aspirin Intolerance

Asthma And Nasal Polyps	Asa Triad
Asthma, Aspirin-Induced, Susceptibility To	Asthma, Aspirin-Induced
Asthma, With Nasal Polyps And Aspirin Intolerance	ANPAI
Aia	Aspirin-Intolerant Asthma
Asthma Aspirin-Induced	Nasal Polyps Asthma And Aspirin Sensitivity
Samter Triad	Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps

Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced

Chronic Frontal Sinusitis

Aspirin Allergy

Acetylsalicylic Acid Allergy

Asa Allergy

Intrinsic Asthma

Non-Atopic Asthma

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-126329	AZD9898	Inhibitor	98.62%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-117143	TK05	Inhibitor	98.00%	否
HY-RS07882	LTC4S Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	LTC4S	VGNC	VGNC:82180
Canis familiaris	LTC4S	VGNC	VGNC:51742
Bos taurus	LTC4S	VGNC	VGNC:31076
Felis catus	LTC4S	VGNC	VGNC:68106
Mus musculus	LTC4S	MGD	MGI:107498
Rattus norvegicus	LTC4S	RGD	RGD:620677
Others	LTC4S	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)	站点地图隐私声明
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.	沪ICP备15051369号-4

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

LTC4S - leukotriene C4 synthase Gene

关于 LTC4S

功能概要

LTC4S 基因产物(1)

LTC4S 蛋白结构

重组 LTC4S 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

LTC4S - leukotriene C4 synthase Gene

关于 LTC4S

功能概要

LTC4S 基因产物(1)

LTC4S 蛋白结构

重组 LTC4S 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z