1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase
  3. AZD9898

AZD9898 

目录号: HY-126329
产品使用指南

AZD9898 是一种口服的白三烯-C4 合成酶 (LTC4S) 抑制剂,IC50 值为 0.28 nM。AZD9898 减轻GABA 结合和肝毒性信号。AZD9898 具有治疗哮喘的潜力。

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AZD9898 Chemical Structure

AZD9898 Chemical Structure

CAS No. : 2042347-69-1

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Description

AZD9898 is an oral leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma[1].

IC50 & Target

IC50: 0.28 nM (LTC4S)[1].

In Vivo

AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised[1].

Animal Model: Rat 6M/group[1].
Dosage: 10 and 100 mg/kg (for Toxicology Study).
Administration: Sing oral dose.
Result: Showed no signs of testicular toxicity, and only adaptive changes in the liver due to cytochrome P450 induction which were not judged adverse, providing a 200 fold margin between the no adverse effect level and the predicted human exposure at the predicted therapeutic dose.
Molecular Weight

457.83

Formula

C₂₀H₁₉ClF₃N₃O₄

CAS No.

2042347-69-1

SMILES

O=C([C@@H]1[C@@H](C(C2=NC=C(N(C3=CC(Cl)=C(F)C=C3F)CC(C)(F)C)N=C2OC)=O)C1)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
AZD9898
目录号:
HY-126329
需求量:

AZD9898

Cat. No.: HY-126329