1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase
  3. TK05

TK05 是一种有效选择性的白三烯 C4 合成酶 (LTC4S) 抑制剂,其 IC50 值为 95 nM。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

TK05 Chemical Structure

TK05 Chemical Structure

CAS No. : 1245734-61-5

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥5940
In-stock
1 mg ¥2160
In-stock
5 mg ¥5400
In-stock
10 mg ¥8800
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1].

IC50 & Target

IC50: 95 nM (Leukotriene C4 synthase)[1]

体外研究
(In Vitro)

TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zymosan A induced peritonitis mouse model[1]
Dosage: 0.12 mg/kg; 6 mg/kg
Administration: Given i.p.; only once
Result: 0.12 mg/kg of TK05 significantly reduced LTE4 levels, whereas 6 mg/kg body weight of the compound resulted in almost complete inhibition compared with mice treated with only Zymosan A.
分子量

540.99

Formula

C31H25ClN2O5

CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 100 mg/mL (184.85 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8485 mL 9.2423 mL 18.4846 mL
5 mM 0.3697 mL 1.8485 mL 3.6969 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8485 mL 9.2423 mL 18.4846 mL 46.2116 mL
5 mM 0.3697 mL 1.8485 mL 3.6969 mL 9.2423 mL
10 mM 0.1848 mL 0.9242 mL 1.8485 mL 4.6212 mL
15 mM 0.1232 mL 0.6162 mL 1.2323 mL 3.0808 mL
20 mM 0.0924 mL 0.4621 mL 0.9242 mL 2.3106 mL
25 mM 0.0739 mL 0.3697 mL 0.7394 mL 1.8485 mL
30 mM 0.0616 mL 0.3081 mL 0.6162 mL 1.5404 mL
40 mM 0.0462 mL 0.2311 mL 0.4621 mL 1.1553 mL
50 mM 0.0370 mL 0.1848 mL 0.3697 mL 0.9242 mL
60 mM 0.0308 mL 0.1540 mL 0.3081 mL 0.7702 mL
80 mM 0.0231 mL 0.1155 mL 0.2311 mL 0.5776 mL
100 mM 0.0185 mL 0.0924 mL 0.1848 mL 0.4621 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
TK05
目录号:
HY-117143
需求量: