LTC4S 蛋白, Human (sf9, His)

LTC4S plays a crucial role in cellular processes by catalyzing the conjugation of leukotriene A4 with reduced glutathione (GSH), yielding the bioactive lipid mediator leukotriene C4 with remarkable specificity. This enzymatic activity is pivotal in the regulation of inflammation and immune responses. Additionally, LTC4S demonstrates versatility by facilitating the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid, resulting in the formation of maresin conjugate in tissue regeneration 1 (MCTR1). Notably, MCTR1 possesses potent anti-inflammatory and proresolving actions, emphasizing the multifaceted nature of LTC4S in mediating lipid metabolism and inflammation. LTC4S Protein, Human (sf9, His) is the recombinant human-derived LTC4S protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of LTC4S Protein, Human (sf9, His) is 150 a.a., with molecular weight of ~17 kDa.

LTC4S 通过催化白三烯 A4 与还原型谷胱甘肽 (GSH) 的结合，产生具有显着特异性的生物活性脂质介质白三烯 C4，从而在细胞过程中发挥着至关重要的作用。这种酶活性对于炎症和免疫反应的调节至关重要。此外，LTC4S 通过促进谷胱甘肽基团从谷胱甘肽 (GSH) 转移到 13(S),14(S)-环氧二十二碳六烯酸，从而在组织再生 1 (MCTR1) 中形成 maresin 缀合物，从而展现出多功能性。值得注意的是，MCTR1 具有有效的抗炎和促消退作用，强调了 LTC4S 在介导脂质代谢和炎症方面的多方面性质。

Human

Sf9 insect cells

C-His

Q16873 (M1-A150)

4056  [NCBI]

Approximately 17 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.