2. Gene
  3. NMT1 - N-myristoyltransferase 1 Gene

NMT1 - N-myristoyltransferase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：N-肉豆蔻酰转移酶 1

种属: Homo sapiens

同用名: NMT; HsNMT1

基因 ID: 4836 | 基因类型: protein coding

关于 NMT1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,061,317-45,109,016 (from NCBI)

This gene has 19 transcripts (splice variants), 281 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 21.5), thyroid (RPKM 17.0) and 25 other tissues.

功能概要

肉豆蔻酸是一种罕见的 14 碳饱和脂肪酸，通过酰胺键共翻译连接到具有多种功能的细胞和病毒蛋白的 N 末端甘氨酸残基上。 N-肉豆蔻酰转移酶 (NMT; EC 2.3.1.97) 催化肉豆蔻酸从 CoA 转移到蛋白质。 N-豆蔻酰化似乎是不可逆的，并且是几种 N-豆蔻酰化蛋白生物活性完全表达所必需的，包括信号转导鸟嘌呤核苷酸结合蛋白 (G 蛋白) GO (GNAO1；MIM 139311) 的 α 亚基 ( Duronio 等人，1992 [PubMed 1570339]) .[OMIM 提供，2008 年 11 月]

Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and Viral Proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

NMT1 基因产物(1)

mRNA Protein Name
NM_021079.5 NP_066565.1 glycylpeptide N-tetradecanoyltransferase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycylpeptide N-tetradecanoyltransferase activity IDA
IDA: 通过直接分析推断
25255805 GOA
enables myristoyltransferase activity IDA
IDA: 通过直接分析推断
22865860 GOA
enables peptidyl-lysine N6-myristoyltransferase activity IDA
IDA: 通过直接分析推断
32103017 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26621918 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-terminal peptidyl-glycine N-myristoylation IDA
IDA: 通过直接分析推断
25255805 GOA
involved in cellular ketone metabolic process IDA
IDA: 通过直接分析推断
22865860 GOA
involved in protein localization to membrane IDA
IDA: 通过直接分析推断
34999170 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9353336 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
9506952 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NMT1 蛋白结构

NMT

NMT: Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain (141 - 294)

NMT_C

NMT_C: Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain (308 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
蛋白主名 其他名称

glycylpeptide N-tetradecanoyltransferase 1

alternative, short form NMT-S

NMT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NMT1 P30419 ACBD6 Homo sapiens Q9BR61
Validated Y2H
32296183
种属内
NMT1 P30419 ACBD6 Homo sapiens Q9BR61
Gal4 VP16 Complement
26621918
种属内
NMT1 P30419 ACBD6 Homo sapiens Q9BR61
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gallbladder Cancer

Gallbladder Carcinoma

Gallbladder Neoplasm

Malignant Neoplasm Of Gallbladder

Malignant Tumour Of Gallbladder

Gallbladder Ca

Localized Malignant Gallbladder Neoplasm

Malignant Tumor Of The Gallbladder

Tumor Of The Gallbladder

Cancer Of The Gallbladder

Carcinoma Gallbladder

Carcinoma Of Gallbladder

Gallbladder Neoplasms

Malignant Neoplasm Of Gallbladder Localized

Cancer Of Gallbladder

Primary Malignant Neoplasm Of Gallbladder
Partial Fetal Alcohol Syndrome
Sleeping Sickness

African Trypanosomiasis

African Sleeping Sickness

Trypanosomiasis, Human East-African

Trypanosomiasis, East African

Trypanosomiasis African

Trypanosomiasis, African

Human African Trypanosomiasis
Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect
Atrial Heart Septal Defect

Atrial Septal Defect

Atrial Septal Defects

Atrioseptal Defect

Auricular Septal Defect

Congenital Atrial Septal Defect

Interatrial Septal Defect

Interauricular Septal Defect

Heart Septal Defects, Atrial

Septal Defect, Atrial
Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency

Mitochondrial Complex Iv Deficiency

Cox Deficiency

Cytochrome-C Oxidase Deficiency Disease

MC1DN4

Cytochrome-C Oxidase Deficiency

MC4DN1

Mitochondrial Complex I Deficiency, Nuclear Type 4

Complex 4 Mitochondrial Respiratory Chain Deficiency

Complex Iv Deficiency

Mitochondrial Complex 1 Deficiency, Nuclear Type 4

Nuclear Type Mitochondrial Complex I Deficiency 4

Deficiency Of Mitochondrial Respiratory Chain Complex4

MT-C4D

Complex Iv Mitochondrial Respiratory Chain Deficiency

Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency

Mitochondrial Complex Iv Deficiency, Nuclear, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112258 IMP-1088 Inhibitor 99.16% 否
HY-147308 Zelenirstat Inhibitor 99.76% 否
HY-RS09389 NMT1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-161045 T-1-DOCA / 否
HY-RS18960 Nmt1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25450 Nmt1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NMT1 VGNC VGNC:68507
Canis familiaris NMT1 VGNC VGNC:43866
Rattus norvegicus NMT1 RGD RGD:628642
Macaca mulatta NMT1 VGNC VGNC:75360
Bos taurus NMT1 VGNC VGNC:32137
Mus musculus NMT1 MGD MGI:102579
Others NMT1 NCBI
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