1. Gene
  2. PPP1CC - protein phosphatase 1 catalytic subunit gamma Gene

PPP1CC - protein phosphatase 1 catalytic subunit gamma Gene

中文名称:蛋白磷酸酶 1 催化亚基 γ

种属: Homo sapiens

同用名: PP1C; PP-1G; PPP1G

基因 ID: 5501 | 基因类型: protein coding

关于 PPP1CC

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,708,376-110,742,891 (from NCBI)

This gene has 11 transcripts (splice variants), 231 orthologues and 12 paralogues. Ubiquitous expression in duodenum (RPKM 77.6), small intestine (RPKM 62.4) and 25 other tissues.

功能概要

该基因编码的蛋白质属于蛋白磷酸酶家族 PP1 亚家族。 PP1 是一种普遍存在的丝氨酸/苏氨酸磷酸酶,可调节许多细胞过程,包括细胞分裂。它在哺乳动物细胞中表达为三种密切相关的亚型,α、β/δ 和γ,它们具有不同的定位模式。该基因编码 γ 同工酶。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2011 年 10 月]

The protein encoded by this gene belongs to the protein Phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine Phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PPP1CC 基因产物(2)

mRNA Protein Name
NM_001244974.2 NP_001231903.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2
NM_002710.4 NP_002701.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1

PPP1CC 蛋白结构

Metallophos

Metallophos: Calcineurin-like phosphoesterase (59 - 250)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase PP1-gamma catalytic subunit

protein phosphatase 1, catalytic subunit, gamma isozyme

重组 PPP1CC 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71228 PPP1CC Protein, Human (His) P36873 (M1-K323) ≥95%

关联疾病

疾病名称 别名
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PPP1CC MGD MGI:104872
Rattus norvegicus PPP1CC RGD RGD:3377
Bos taurus PPP1CC VGNC VGNC:53916
Canis familiaris PPP1CC VGNC VGNC:52957
Felis catus PPP1CC VGNC VGNC:80466
Others PPP1CC NCBI