CD2BP2 - CD2 cytoplasmic tail binding protein 2 Gene

中文名称：CD2 胞质尾部结合蛋白 2

种属: Homo sapiens

同用名: LIN1; Snu40; FWP010; U5-52K; PPP1R59

关于 CD2BP2

功能概要

该基因编码一种双功能蛋白。在细胞质中，编码的蛋白质通过其 C 末端 GYF 结构域结合人表面抗原 CD2 的细胞质尾部，并调节 CD2 触发的 T 淋巴细胞活化。在细胞核中，该蛋白是 U5 小核核糖核蛋白复合物的组成部分，参与 RNA 剪接。已在 7 号染色体上鉴定出一个假基因。可变剪接导致多个转录本变体，但尚未确定其生物学有效性。[RefSeq 提供，2008 年 11 月]

This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]