PRMT6 - protein arginine methyltransferase 6 Gene

中文名称：蛋白质精氨酸甲基转移酶 6

种属: Homo sapiens

同用名: HRMT1L6

关于 PRMT6

功能概要

该基因编码的蛋白质属于精氨酸 N-甲基转移酶家族，催化甲基从 S-腺苷-L-甲硫氨酸依次转移到蛋白质内精氨酸残基的侧链氮上，形成甲基化的精氨酸衍生物和 S-腺苷-L-高半胱氨酸。这种蛋白质可以催化 omega-N 单甲基精氨酸和不对称二甲基精氨酸的形成，对后者有强烈的偏好。它专门介导组蛋白 H3 的 Arg2 的不对称二甲基化，甲基化形式代表表观遗传转录抑制的特定标签。该蛋白质还与 DNA 聚合酶 β 形成复合物并甲基化 DNA 聚合酶 β，从而通过增强 DNA 结合和持续合成能力来刺激聚合酶活性。[RefSeq 提供，2011 年 9 月]

The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]