1. Epigenetics
  2. Histone Methyltransferase
  3. SGC2085 hydrochloride

SGC2085 hydrochloride 是一种有效的选择性共激活剂相关精氨酸甲基转移酶 1 (CARM1) 抑制剂,IC50 为 50 nM。SGC2085 hydrochloride 还选择性抑制 PRMT6IC50 为 5.2 μM,但不抑制其他 PRMT 蛋白。

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SGC2085 hydrochloride Chemical Structure

SGC2085 hydrochloride Chemical Structure

CAS No. : 1821908-49-9

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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SGC2085 hydrochloride 的其他形式现货产品:

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Other Forms of SGC2085 hydrochloride:

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

生物活性

SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC50 of 50 nM. SGC2085 hydrochloride also selectively inhibits PRMT6 with an IC50 value of 5.2 μM, but not other PRMT proteins[1].

IC50 & Target[1]

PRMT6

5.2 μM (IC50)

体外研究
(In Vitro)

SGC2085 hydrochloride (1 μM, 10 μM, 50 μM;48 h) 对 21 种人类蛋白质甲基转移酶的具有完全选择性[1]
SGC2085 hydrochloride (10 μM;48 h) 表现出低细胞渗透性,在 HEK293 细胞中无细胞活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

348.87

Formula

C19H25ClN2O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
Cell Assay
[1]

SGC2085 is dissolved in DMSO and diluted with appropriate medium before use. HEK293 cells are grown in 12-well plates in DMEM supplemented with 10% FBS, penicillin (100 U/mL), and streptomycin (100 μg/mL). Thirty percent confluent cells are treated with inhibitors or DMSO. After 48 h, media are removed and cells are lysed in 100 μL of total lysis buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 1 mM EDTA, 10 mM MgCl2, 0.5% Triton X-100, 12.5 U/mL benzonase), complete EDTA-free protease inhibitor cocktail. After 3 min incubation at room temperature, SDS is added to 1% final concentration. Lysates are run on SDS-PAGE, and immunoblotting is done as outlined below to determine the levels of unmethylated and methylated BAF155[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SGC2085 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SGC2085 hydrochloride
目录号:
HY-100565A
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