PRKAB2 - protein kinase AMP-activated non-catalytic subunit beta 2 Gene

中文名称：蛋白激酶 AMP 激活的非催化亚基 β 2

种属: Homo sapiens

关于 PRKAB2

功能概要

该基因编码的蛋白质是 AMP 活化蛋白激酶 (AMPK) 的调节亚基。 AMPK 是一种异源三聚体，由一个 α 催化亚基以及非催化 β 和 γ 亚基组成。 AMPK 是一种重要的能量感应酶，可监测细胞能量状态。响应细胞代谢应激，AMPK 被激活，从而使乙酰辅酶 A 羧化酶 (ACC) 和 β-羟基β-甲基戊二酰辅酶 A 还原酶 (HMGCR) 磷酸化和失活，这些酶是参与调节脂肪酸和胆固醇从头生物合成的关键酶.该亚基可能是 AMPK 活性的正调节因子。它在骨骼肌中高度表达，因此可能具有组织特异性作用。已发现该基因的多个选择性剪接转录物变体。[RefSeq 提供，2013 年 7 月]

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing Enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]