NFKBIZ - NFKB inhibitor zeta Gene

中文名称：NFKB 抑制因子 zeta

种属: Homo sapiens

同用名: IKBZ; INAP; MAIL

关于 NFKBIZ

功能概要

该基因是锚蛋白重复家族的成员，由脂多糖 (LPS) 诱导。包含锚蛋白重复序列的编码产物的 C 端部分与 I kappa B 蛋白家族具有高度序列相似性。已知后者通过锚蛋白重复结构域与 NF-B 蛋白相互作用，在对 LPS 的炎症反应中发挥作用。小鼠研究表明，该基因产物是核 I kappa B 蛋白之一，也是 IL-6 生成的激活剂。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]