2. Gene
  3. THBS2 - thrombospondin 2 Gene

THBS2 - thrombospondin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：血小板反应蛋白 2

种属: Homo sapiens

同用名: TSP2

基因 ID: 7058 | 基因类型: protein coding

关于 THBS2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:169,215,785-169,253,846 (from NCBI)

This gene has 15 transcripts (splice variants), 276 orthologues, 5 paralogues and is associated with 1 phenotype. Broad expression in gall bladder (RPKM 49.1), endometrium (RPKM 31.3) and 18 other tissues.

功能概要

该基因编码的蛋白质属于血小板反应蛋白家族。它是一种二硫键连接的同源三聚体糖蛋白，可介导细胞与细胞和细胞与基质的相互作用。这种蛋白质已被证明可作为肿瘤生长和血管生成的有效抑制剂。对小鼠对应物的研究表明，这种蛋白质可能调节间充质细胞的细胞表面特性，并参与细胞粘附和迁移。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]

THBS2 基因产物(5)

mRNA Protein Name
NM_001381939.1 NP_001368868.1 thrombospondin-2 isoform 2 precursor
NM_001381940.1 NP_001368869.1 thrombospondin-2 isoform 3 precursor
NM_001381941.1 NP_001368870.1 thrombospondin-2 isoform 4 precursor
NM_001381942.1 NP_001368871.1 thrombospondin-2 isoform 5
NM_003247.5 NP_003238.2 thrombospondin-2 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19818485 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of angiogenesis IDA
IDA: 通过直接分析推断
20714802 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in platelet alpha granule IDA
IDA: 通过直接分析推断
1737102 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

THBS2 蛋白结构

VWC

VWC: von Willebrand factor type C domain (320 - 374)

TSP_1

TSP_1: Thrombospondin type 1 domain (385 - 430)

TSP_1

TSP_1: Thrombospondin type 1 domain (441 - 491)

TSP_1

TSP_1: Thrombospondin type 1 domain (498 - 548)

EGF_CA

EGF_CA: Calcium-binding EGF domain (590 - 630)

EGF_3

EGF_3: EGF domain (652 - 691)

TSP_3

TSP_3: Thrombospondin type 3 repeat (729 - 764)

TSP_3

TSP_3: Thrombospondin type 3 repeat (764 - 787)

TSP_3

TSP_3: Thrombospondin type 3 repeat (789 - 823)

TSP_3

TSP_3: Thrombospondin type 3 repeat (824 - 846)

TSP_3

TSP_3: Thrombospondin type 3 repeat (847 - 884)

TSP_3

TSP_3: Thrombospondin type 3 repeat (886 - 920)

TSP_3

TSP_3: Thrombospondin type 3 repeat (921 - 952)

TSP_C

TSP_C: Thrombospondin C-terminal region (974 - 1171)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1172 a.a.
蛋白主名 其他名称

thrombospondin-2

THBS2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
THBS2 P35442 Cacna2d1 Rattus norvegicus P54290
Anti Tag CoIP
19818485
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 THBS2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78725 Thrombospondin-2 Protein, Human (HEK293, His) P35442-1 (G19-I1172) ≥95%

关联疾病

疾病名称 别名
Intervertebral Disc Disease

Lumbar Disc Disease

Intervertebral Disc Disorder

IDD

Lumbar Disc Herniation

Lumbar Disc Degeneration

Intervertebral Disc Disease, Susceptibility To

Lumbar Disc Herniation, Susceptibility To

Lumbar Disc Disease, Susceptibility To

Intervertebral Disc Degeneration

Discogenic Disease

Discogenic Disorder

Disorder Of Intervertebral Disc

Intervertebral Disk Degeneration

Intervertebral Disk Disease

Ldd

Ldh

Lumbar Disc Degeneration, Susceptibility To

Degeneration Of Lumbar Intervertebral Disc

Intervertebral Disk Displacement
Back Pain
Spinal Stenosis

Lumbar Spinal Stenosis

Cervical Spinal Stenosis

Spinal Stenosis Of Lumbar Region

Spinal Stenosis In Cervical Region

Spinal Canal Stenosis
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
Intestinal Schistosomiasis

Schistosomiasis Japonica

Schistosomiasis Mansoni

Katayama Fever

Schistosoma Japonicum Infection

Schistosoma Mansoni Infectious Disease

Schistosomiasis
Urinary Schistosomiasis

Schistosoma Haematobium Infection

Schistosoma Hematobium Infection

Schistosomiasis Due To Schistosoma Haematobium

Bladder Schistosomiasis

Cystitis With Bilharziasis

Schistosoma Haematobium

Schistosoma Hematobium Infectious Disease

Schistosomiasis Of Bladder

Vesical Schistosomiasis

Schistosomiasis Urinary

Schistosomiasis Haematobia

Genitourinary Bilharziasis

Genitourinary Tract Schistosomiasis

Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis]

Haematochyluria In Schistosomiasis

Infection Due To Schistosoma Matthei
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS23968 Thbs2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14480 THBS2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17511 Thbs2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus THBS2 VGNC VGNC:66155
Bos taurus THBS2 VGNC VGNC:35829
Mus musculus THBS2 MGD MGI:98738
Macaca mulatta THBS2 VGNC VGNC:104433
Canis familiaris THBS2 VGNC VGNC:47336
Rattus norvegicus THBS2 RGD RGD:1310979
Others THBS2 NCBI
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