NCOA4 - nuclear receptor coactivator 4 Gene

中文名称：核受体共激活因子 4

种属: Homo sapiens

同用名: RFG; ELE1; PTC3; ARA70

基因 ID: 8031 | 基因类型: protein coding

关于 NCOA4

Cytogenetic location: 10q11.22 Genomic coordinates (GRCh38): 10:46,005,088-46,030,623 (from NCBI)

This gene has 7 transcripts (splice variants), 216 orthologues and is associated with 17 phenotypes. Ubiquitous expression in duodenum (RPKM 113.8), liver (RPKM 75.2) and 25 other tissues.

功能概要

该基因编码雄激素受体共激活因子。编码的蛋白质以配体依赖性方式与雄激素受体相互作用，以增强其转录活性。该基因与同样位于 10 号染色体上的 RET 酪氨酸激酶基因之间的染色体易位与甲状腺乳头状癌有关。已经描述了选择性剪接的转录物变体。假基因存在于 4、5、10 和 14 号染色体上。[RefSeq 提供，2009 年 2 月]

This gene encodes an Androgen Receptor coactivator. The encoded protein interacts with the Androgen Receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the RET tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

NCOA4 基因产物(5)

mRNA	Protein	Name
NM_001145260.2	NP_001138732.1	nuclear receptor coactivator 4 isoform 1
NM_001145261.2	NP_001138733.1	nuclear receptor coactivator 4 isoform 2
NM_001145262.2	NP_001138734.1	nuclear receptor coactivator 4 isoform 3
NM_001145263.2	NP_001138735.1	nuclear receptor coactivator 4 isoform 3
NM_005437.4	NP_005428.1	nuclear receptor coactivator 4 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within protein targeting to lysosome	IDA IDA: 通过直接分析推断	25327288	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in autolysosome	IDA IDA: 通过直接分析推断	25327288	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCOA4 蛋白结构

ARA70

0
100
200
300
400
500
614 a.a.

蛋白主名

其他名称

nuclear receptor coactivator 4

70 kDa AR-activator

NCOA4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NCOA4	Q13772	FTL	Homo sapiens	P02792	Anti Tag CoIP	33961781
种属内	NCOA4	Q13772	FTL	Homo sapiens	P02792	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

NCOA4 抗体

目录号	产品名	应用	反应物种
HY-P84934	NCOA4 Antibody (YA4630)	WB	Human
HY-P84935	NCOA4 Antibody (YA4631)	IHC-P, IF-Tissue	Human, Mouse, Rat

关联疾病

疾病名称

别名

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma	Well-Differentiated Thyroid Carcinoma
Differentiated Thyroid Gland Carcinoma

Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome

Papillary Carcinoma

Carcinoma, Papillary

Carcinoma Papillary

Hashimoto Thyroiditis

Autoimmune Thyroiditis	Hashimoto Struma
Hashimoto'S Thyroiditis	Chronic Lymphocytic Thyroiditis
Lymphocytic Thyroiditis	Hashimoto Disease
Ht	Hashimoto'S Disease
Hashimoto'S Syndrome	Hypothyroidism, Autoimmune
Autoimmune Chronic Lymphocytic Thyroiditis	Chronic Lymphocytic Thyroiditides
Hashimoto Syndrome	Hashimotos Thyroiditis
Hashimoto Thyroiditis, Susceptibility To	Thyroiditis, Autoimmune
Lymphomatous Thyroiditis	Lymphoid Thyroiditis
Chronic Lymphadenoid Thyroiditis	Autoimmune Lymphocytic Chronic Thyroiditis
Goitre Lymphomatosa	Hashitoxicosis
Hashimoto Hypothyroidism	Lymphadenoid Goitre
Struma Lymphomatosa	Hyperthyroidism With Hashimoto Disease
Hashimoto Thyrotoxicosis	Thyrotoxicosis Due To Hashimoto Thyroiditis
Struma Lymphomatosis	Lymphadenoid Struma

Thyroid Gland Cancer

Thyroid Gland Carcinoma	Malignant Neoplasm Of Thyroid Gland
Malignant Tumour Of Thyroid Gland	Thyroid Neoplasm
Thyroid Neoplasms	Neoplasm Of Thyroid Gland
Thyroid Gland Neoplasm	Head And Neck Cancer, Thyroid
Neoplasm Of The Thyroid Gland	Cancer Of The Thyroid
Primary Malignant Neoplasm Of Thyroglossal Duct	Malignant Neoplasm Of Thyroglossal Duct
Primary Malignant Neoplasm Of Thyroid Gland	Thyroglossal Duct Cancer
Toxic Goitre Malignant Tumour	Cancerous Goitre

Benign Struma Ovarii

Multiple Endocrine Neoplasia, Type Iib

Multiple Endocrine Neoplasia Type 2b	MEN2B
Wagenmann-Froboese Syndrome	Multiple Endocrine Neoplasia Iib
Mucosal Neuroma Syndrome	Multiple Endocrine Neoplasia, Type 3
Multiple Endocrine Neoplasia, Type 2b	Men Iib
Neuromata, Mucosal, With Endocrine Tumors	Multiple Endocrine Neoplasia, Type Iii, Formerly
Men3, Formerly	Men Type Iib
Men 2b	Multiple Endocrine Neoplasia Type 3
Multiple Neoplasia 2b	Neoplasia, Endocrine, Multiple, Type Iib

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Ovarian Germ Cell Teratoma

Germ Cell Teratoma Of Ovary

Ovarian Teratoma

Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma	Follicular Adenocarcinoma
Follicular Adenocarcinoma, Well Differentiated	Follicular Carcinoma
Thyroid Adenocarcinoma	Adenocarcinoma, Follicular

Struma Ovarii

Thyroid Gland Medullary Carcinoma

Medullary Thyroid Carcinoma	Medullary Carcinoma Of The Thyroid Gland
Ultimobranchial Thyroid Tumor	Ultimobranchial Thyroid Tumour
Thyroid Cancer, Medullary

Malignant Struma Ovarii

Struma Ovarii, Malignant

Multinodular Goiter

Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma	Anaplastic Thyroid Cancer
Thyroid Cancer, Anaplastic	Thyroid Carcinoma, Anaplastic
Thyroid Carcinoma Anaplastic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-163897	PROTAC NCOA4 degrader-1	Inhibitor	99.42%	否
HY-RS09092	NCOA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-173119	SKLB-D18		/	否
HY-138678B	(S,R,R)-VH032		/	否
HY-163904	(S,R,R)-VH032-CO-C3-CONH-C2-PEG3-OH		/	否
HY-168894	CT-1	Inducer	/	否
HY-RS16942	Ncoa4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23385	Ncoa4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	NCOA4	VGNC	VGNC:68433
Rattus norvegicus	NCOA4	RGD	RGD:1563014
Mus musculus	NCOA4	MGD	MGI:1350932
Macaca mulatta	NCOA4	VGNC	VGNC:97794
Canis familiaris	NCOA4	VGNC	VGNC:43661
Bos taurus	NCOA4	VGNC	VGNC:31922

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NCOA4 - nuclear receptor coactivator 4 Gene

关于 NCOA4

功能概要

NCOA4 基因产物(5)

NCOA4 蛋白结构

NCOA4 蛋白互作信息

NCOA4 抗体

关联疾病

直系同源

热门区域

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NCOA4 - nuclear receptor coactivator 4 Gene

关于 NCOA4

功能概要

NCOA4 基因产物(5)

NCOA4 蛋白结构

NCOA4 蛋白互作信息

NCOA4 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z