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  4. Glucoraphasatin potassium

Glucoraphasatin (potassium) 是 Glucoraphasatin (HY-N11822) 的钾盐。Glucoraphasatin 是一种非典型的有口服活性的硫代葡萄糖苷，存在于十字花科蔬菜中，如萝卜 (Raphanus sativus)。Glucoraphasatin 具有抗炎和抗氧化活性。Glucoraphasatin 能够影响 Ⅰ 相代谢酶的活性。Glucoraphasatin 在植物酶黑芥子酶的作用下可转化为异硫氰酸盐，并对癌细胞表现出细胞毒性。Glucoraphasatin 可用于癌症和炎症相关研究，如结肠癌研究。

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Glucoraphasatin potassium

Glucoraphasatin potassium Chemical Structure

CAS No. : 245550-64-5

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Glucoraphasatin potassium 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glucoraphasatin (potassium) is potassium salt of Glucoraphasatin (HY-N11822). Glucoraphasatin is an atypical and orally active glucosinolate found in cruciferous vegetables, including Raphanus sativus. Glucoraphasatin exhibits anti-inflammation and anti-oxidant activity. Glucoraphasatin can affect phase I metabolic enzymes activity. Glucoraphasatin can be converted by the plant enzyme myrosinase into isothiocyanates and shows cytotoxic to cancer cells. Glucoraphasatin can be used for the researches of cancer and inflammation, such as colon cancer[1][2].

体外研究
(In Vitro)

Glucoraphasatin 对 H2O2 和 ABTS+ 自由基均具有还原能力[1]。
Glucoraphasatin (50 μM, 3-6 days) 与黑芥子酶联用，可抑制 LoVo、HCT-116 和 HT-29 细胞的增殖[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Glucoraphasatin potassium 相关抗体:
体内研究
(In Vivo)

Glucoraphasatin (120 mg/kg，口服，每日一次，持续 1 天或 4 天) 会影响 SD 大鼠的 I 相代谢酶活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[1]
Dosage: 120 mg/kg
Administration: Orally administration, daily for 1 or 4 days
Result: Resulted in a 2.4-fold increase in CYP3A1/2-linked monooxygenase (aminopyrine N-demethylase) and a 1.6-fold increase in CYP1A2-supported monooxygenase (methoxyresorufin O-demethylase).
Increased CYP1A1-linked monooxygenase (ethoxyresorufin O-deethylase) and the CYP2B1/2-supported oxidase (pentoxyresorufin O-dealkylase) by 1.5-fold.
Reduced CYP2E1-linked monooxygenase (p-nitrophenolhydroxylase) activity.
分子量

457.58

Formula

C12H20KNO9S3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glucoraphasatin potassium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucoraphasatin245550-64-5OthersCruciferous vegetablesRaphanus sativusMyrosinaseColon cancerInhibitorinhibitorinhibit

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