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  3. Amino Acid Derivatives
  4. H-Gly-Sar-Sar-OH

H-Gly-Sar-Sar-OH 是一种具有口服活性的三肽。H-Gly-Sar-Sar-OH 通过 PepT1 在 Caco-2 细胞内转运。H-Gly-Sar-Sar-OH 在物质运输有潜在应用。

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Custom Peptide Synthesis

H-Gly-Sar-Sar-OH Chemical Structure

H-Gly-Sar-Sar-OH Chemical Structure

CAS No. : 57836-11-0

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H-Gly-Sar-Sar-OH 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation[1][2][3].

体内研究
(In Vivo)

H-Gly-Sar-Sar-OH (0.1 mM；灌注；单剂量) 在 Sprague-Dawley 大鼠肾脏中未显著被水解 (给药 60 min) 或清除[2]。
H-Gly-Sar-Sar-OH (10 mg/kg；口服；单剂量) 在自发性高血压大鼠 (SHRs) 中显示出稳定性[3]。
H-Gly-Sar-Sar-OH 在自发性高血压大鼠中的药代动力学 (PK) 参数[3]

Week old Cmax (nmol/mL, plasma) Tmax (min) AUC0-90 min (nmol•min/mL, plasma) T1/2 (min)
8 4.6±0.6 30 258.0±32.1 75
40 10.7±1.5 30 621.0±86.3 83

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (350 g)[2].
Dosage: 0.1 mM.
Administration: Perfusion (kidney); single dose.
Result: Showed stability.
Animal Model: Male SHRs (8 and 40 week-old)[3].
Dosage: 10 mg/kg.
Administration: Oral gavage; single dose.
Result: Detected in full form.
分子量

217.22

Formula

C8H15N3O4
CAS 号
Sequence

H-Gly-Sar-Sar-OH
Sequence Shortening

G-{Sar}-{Sar}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

H-Gly-Sar-Sar-OH 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-Gly-Sar-Sar-OH57836-11-0Amino Acid DerivativesSprague-Dawley ratsSpontaneously hypertensive ratsSHRsInhibitorinhibitorinhibit

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