2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Herboxidiene

Herboxidiene  (Synonyms: GEX1A)

目录号: HY-19828 纯度: ≥99.0%
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摩尔计算器

Herboxidiene (GEX1A) 是一种有效的植物毒性聚酮类化合物，来源于链霉菌 A7847，具有多种活性，包括除草、抗胆固醇、抗肿瘤等。Herboxidiene 通过与剪接体相关蛋白 (SAP) 155 结合抑制前 mRNA 剪接 (pre-mRNA splicing) 过程，SAP 是剪接体中 SF3b 的一个亚单位。

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Herboxidiene Chemical Structure

Herboxidiene Chemical Structure

CAS No. : 142861-00-5

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规格 价格 是否有货 数量
500 μg ￥11700
In-stock
1 mg ￥18600
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Herboxidiene 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome[1][2].

体外研究
(In Vitro)

Herboxidiene (24 hours) induces both G1 and G2/M arrest in a human normal fibroblast cell line, WI-38, with an IC50 of 7.6 nM[3].
Herboxidiene exhibits cytotoxicity against A431, A549, and DLD-1 cells with IC50s of 3.7, 21, 51 nM, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Herboxidiene 相关抗体:
体内研究
(In Vivo)

Herboxidiene (GEX1A) (1 mg/kg; i.p.; once) shows significant antitumor activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (bearing SVT2 murine fibrosarcoma)[3]
Dosage: 1 mg/kg
Administration: I.p.; once
Result: Showed significant antitumor activity on day 4.
分子量

438.60

Formula

C25H42O6
CAS 号
性状

固体

颜色

White to yellow

结构分类
初始来源

Streptomyces chromofuscus A7847
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料
参考文献

Herboxidiene 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Herboxidiene142861-00-5GEX1ADNA/RNA Synthesisphytotoxicpolyketideherbicidalanti-cholesterolanti-tumorspliceosomecellcyclearrestweedSF3bInhibitorinhibitorinhibit

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