HNMPA-(AM)3 

HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC₅₀=14.2 μM) and insulin receptor activity (IC₅₀ is 14.2 μM and 200 μM in mosquitoes and mammals, respectively)^[1][2].

IC50: 14.2 μM (ecdysteroid production), 14.2 μM (mosquito insulin receptor), 200 μM (mammalian insulin receptor))^[2]

454.36

C₂₀H₂₃O₁₀P

120944-03-8

油状物

Colorless to light yellow

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Riehle MA, et al. Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes aegypti. Insect Biochem Mol Biol. 1999 Oct;29(10):855-60.  [Content Brief]

  [2]. Gu SH, et al. PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca²⁺/calmodulin and receptor tyrosine kinase. J Insect Physiol. 2010;56(1):93-101.  [Content Brief]