2. Immunology/Inflammation
  3. CD3
  4. HPN536

HPN536 是一种三特异性 T 细胞活化蛋白构建体，可与表达间皮素的肿瘤细胞、T 细胞上的 CD3ε 和血清白蛋白结合。HPN536 特异性重定向T细胞，以强效重定向裂解表达间皮素的癌细胞，同时激活 T 细胞。

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规格 价格 是否有货 数量
1 mg ￥5000
In-stock
5 mg ￥15000
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

HPN536 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HPN536 is a trispecific, T-cell-activating protein-based construct, which binds to mesothelin-expressing tumor cells, CD3ε on T cells, and to serum albumin. HPN536 specifically redirects T cells for potent redirected lysis of mesothelin-expressing cancer cells with concomitant T-cell activation[1].

反应种属

Human
IC50 & Target

CD3e & Mesothelin & Serum Albumin
Clinical Trial
基因 ID

916  [NCBI] & 10232  [NCBI] & 213  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

52.90 kDa

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Loaded HPN536 on SA biosensor, can bind Mesothelin Protein, Human (303a.a, HEK293, His, HY-P70148) with an affinity constant of 4.442E-10 M as determined in BLI assay.
纯度 & 产品资料
参考文献

HPN536 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPN536HPN 536HPN-536CD3Cluster of differentiation 3Inhibitorinhibitorinhibit

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产品名称：
HPN536
目录号：
HY-P991088
需求量：

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